右美托咪定对剖宫产妇女缩宫素诱导的子宫收缩影响  

Effects of dexmedetomidine on the oxytocin-induced uterine contractions of w omen delivered by cesarean section

作　　者：王静 韩晓东 WANG Jing;HAN Xiaodong(Wenzhou Central Hospital,Wenzhou,Zhejiang Province,325000)

机构地区：[1]浙江省温州市中心医院,325000

出　　处：《中国计划生育学杂志》2023年第3期542-546,共5页Chinese Journal of Family Planning

摘　　要：目的:探讨右美托咪定对剖宫产术中缩宫素诱导的镇痛、子宫收缩的影响。方法:选取2021年2月-2022年6月在本院进行剖宫产手术孕妇96例,手术过程中静脉给予右美托咪定为右美托咪定组或生理盐水为对照组,每组48例。评估两组麻醉前(T0)、麻醉后10 min(T1)、右美托咪定后10 min(T2)和手术结束时(T3)的心率(HR)、收缩压(SBP)和舒张压(DBP),视觉模拟(VAS)评分、Ramsay评分以及子宫收缩强度,记录两组术中不良反应。结果:两组与T0比较,T1、T2、T3时HR、SBP和DBP均有波动,且在使用右美托咪定和缩宫素后表现尤为明显,右美托咪定组比对照组更明显;T2、T3时右美托咪定组宫缩痛VAS评分(0.78±0.51分、0.88±0.41分)低于对照组(2.08±1.01分、2.45±0.87分),Ransay评分(2.45±1.04分、2.41±0.78分)高于对照组(1.47±0.88分、1.45±0.55分)(均P<0.05);子宫收缩评分无差异(P>0.05);右美托咪定组发生恶心(10.4%)、呕吐(2.1%)和低血压(27.1%)比例均低于对照组(39.6%、12.5%、58.3%),心动过缓发生率(62.5%)高于对照组(31.3%)(均P<0.05)。结论:右美托咪定对剖宫产术中缩宫素诱导的子宫收缩无显著影响,镇痛镇静效果更好,利于减少并发症发生。Objective:To investigate the effects of dexmedetomidine on the oxytocin-induced uterine contractions of women delivered by cesarean section.Methods:96 women who underwent cesarean section were selected and were divided in two groups(48 cases in each group)from February 2021 to June 2022.During cesarean section,the women in the study group were given intravenous administration of dexmedetomidine and the women in the control group were given normal saline.The values of heart rate(HR),systolic blood pressure(SBP),and diastolic blood pressure(DBP),the scores of VAS and Ramsay,and the uterine contraction intensity of the women in the two groups before anesthesia(T0),at 10 min after anesthesia(T1),at 10 min after dexmedetomidine(T2),and at the end of surgery(T4)were evaluated.The occurrence of intraoperative adverse reactions of the women in the two groups was recorded.Results:The values of HR,SBP,and DBP of the women in the two groups fluctuated at T1,T2,and T3,especially the women in the study group,and which of the women in the study group were significantly more than those of the women in the control group.The VAS scores of the women in the study group at T2 and T3(0.78±0.51 points and 0.88±0.41 points)were significantly lower than those(2.08±1.01 points and 2.45±0.87 points)of the women in the control group.The Ransay score of the women in the study group at T2 and T3(2.45±1.04 points and 2.41±0.78 points)were significantly higher than those(1.47±0.88 points and 1.45±0.55 points)of the women in the control group(all P<0.05).There was no significant difference in the uterine contraction score of the women between the two groups(P>0.05).The incidences of nausea(10.4%),vomiting(2.1%),and hypotension(27.1%)of the women in the study group were significantly lower than those(39.6%,12.5%,and 58.3%)of the women in the control group,and the incidence of bradycardia(62.5%)of the women in the study group was significantly higher than that(31.3%)of the women in the control group(all P<0.05).Conclusion:Dexmedetomidine

关 键 词：剖宫产术 右美托咪定 缩宫素 子宫收缩 镇痛 镇静 影响 

分 类 号：R614[医药卫生—麻醉学]