复发性流产再孕早期流产因素分析及胎盘绒毛跨膜蛋白CD81、血管生成素评估价值  

Influence factors of early spontaneous abortion of women with recurrent spontaneous abortion and the evaluation values of the levels of placental chorionic transmembrane protein CD81 and angiopoietin for their abortion occurrence

作　　者：邹小雪 赵艳华 ZOU Xiaoxue;ZHAO Yanhua(Wuhan Central Hospital of China Construction Third Engineering Bureau,Wuhan,Hubei Province,430070)

机构地区：[1]中国建筑第三工程局武汉中心医院,430070

出　　处：《中国计划生育学杂志》2023年第3期581-585,共5页Chinese Journal of Family Planning

摘　　要：目的:探讨复发性流产女性再妊娠胎盘绒毛跨膜蛋白CD81、血管生成素(Ang)水平及评估早孕自然流产发生价值。方法:选取2019年6月-2021年3月本院就诊的复发性流产再孕早期自然流产105例纳入流产组,正常早孕要求人工流产终止妊娠110例纳入对照组,通过实时荧光定量PCR(qRT-PCR)法检测两组胎盘绒毛中CD81、Ang1、Ang2 mRNA水平,采用受试者工作曲线(ROC)分析上述3项指标对复发性流产女性再孕流产的评估价值,通过logistic回归分析复发性流产再孕流产发生的危险因素。结果:流产组胎盘绒毛组织CD81(2.33±0.51)、Ang1(0.36±0.11)、Ang2(0.38±0.12)mRNA表达水平均高于对照组(1.67±0.33、0.18±0.05、0.17±0.04)(均P<0.05);胎盘绒毛组织CD81、Ang1、Ang2 mRNA联合检测评估复发流产再孕自然流产的曲线下面积为0.898,高于各指标单独检测(0.786、0.817、0.801)(P<0.05);生殖系统感染、内分泌异常、合并自身免疫性疾病、胎盘绒毛组织CD81 mRNA、Ang1 mRNA、Ang2 mRNA高表达是复发性流产女性再孕自然流产发生的危险因素。结论:复发性流产女性再孕自然流产的发生与胎盘绒毛组织中CD81、Ang1、Ang2高表达有关,检测该3项指标可在一定程度上评估复发性流产再发生。Objective:To explore the levels of placental chorionic transmembrane protein CD81 and angiopoietin(Ang)during prepregnancy of women with recurrent spontaneous abortion(RSA),and to study their values for evaluating the occurrence of spontaneous abortion again of the women during the first trimester of pregnancy.Methods:A total of 105 women with RSA and spontaneous abortion again during the first trimester of pregnancy in the hospital were enrolled in study group between June 2019 and March 2021,and other 110 women with normal pregnancy who wanted termination pregnancy during the first trimester of pregnancy were enrolled in control group.The levels of CD81,Angl mRNA,and Ang2 mRNA in placental villi of the women in the two groups were detected by real-time fluorescence quantification PCR(qRT-PCR),and the evaluation values of which for recurrent spontaneous abortion was analyzed by receiver operating characteristic(ROC)eurve.The risk factors of spontaneous abortion again of the women with RSA during the first trimester of pregnancy were analyzed by Logistic regression analysis.Results:The mRNA expression levels of CD81(2.33±0.51),Angl(0.36±0.11),and Ang2(0.38±0.12)of the women in the study group were significantly higher than those(1.67±0.33,0.18±0.05,and 0.17±0.04)of the women in the control group(all P<0.05).The area under the curve of the combined detections of the levels of CD81 mRNA,Ang1 mRNA,and Ang2 mRNA in placental villi tissue of the women for evaluating their RSA was 0.898,which were significantly higher than that(0.786,0.817,or 0.801)of CD81 mRNA level,Angl mRNA level,or Ang2 mRNA level alone(P<0.05).The reproductive system infection,endocrine abnormalities,autoimmune diseases,high expression levels of CD81 mRNA,Angl mRNA,and Ang2 mRNA in placental villi of the women with RSA were the risk factors of their spontaneous abortion again.Conclusion:The occurrence of remiscarriage of the women with RSA and spontaneous abortion again during the first trimester of pregnancy is related to their high mRNA ex

关 键 词：复发性流产 早孕期 胎盘绒毛组织 跨膜蛋白CD81 血管生成素 评估 

分 类 号：R714.21[医药卫生—妇产科学]