多囊卵巢综合征不孕女性血清INHB、AMH、bFSH水平及评估卵巢储备功能价值  

Levels of inhibin B,anti Mullerian hormone,and basal follicle stimulating hormone of women with inferility induced by polycystic ovary syndrome and their evaluative values for ovarian reserve function

作　　者：蔡理 孙涛声 CAI Li;SUN Taosheng(Fengdu County Hospital of Traditional Chinese Medicine,Chongqing,408200;Pengshui Miao and Tujia Autonomous County Hospital of Traditional Chinese Medicine,Chongqing)

机构地区：[1]重庆市丰都县中医院,408200 [2]重庆市彭水苗族土家族自治县中医院

出　　处：《中国计划生育学杂志》2023年第3期586-589,共4页Chinese Journal of Family Planning

摘　　要：目的:探究抑制素B(INHB)、抗苗勒氏管激素(AMH)及基础卵泡刺激素(bFSH)水平在多囊卵巢综合征(PCOS)不孕女性卵巢储备功能评估价值。方法:回顾性收集2019年10月-2020年10月本院收治PCOS不孕患者87例(不孕组),体检健康女性53例(对照组),测定血清INHB、AMH、bFSH水平;不孕组根据超声检测卵巢获卵数分为卵巢低反应与正常反应,分析3指标对患者卵巢储备功能的评估价值。结果:不孕组血清INHB(149.78±36.92 pg/ml)、AMH(10.94±3.21 ng/ml)水平高于对照组(96.85±31.29 pg/ml、3.29±0.95 ng/ml),bFSH水平(13.08±3.41 IU/L)低于对照组(16.29±4.74 IU/L),且不孕组卵巢低反应患者血清INHB、AMH水平高于卵巢正常反应患者,bFSH水平低于卵巢正常反应患者(均P<0.05);Pearson相关性分析,不孕组血清INHB与AMH、bFSH呈正相关(r=0.516)、负相关(-0.637),AMH与bFSH呈负相关(r=-0.453)(均P<0.05);受试者工作特征曲线显示,血清INHB、AMH、bFSH水平评估卵巢储备功能的曲线下面积(AUC)值分别为0.726、0.774、0.695,3指标联合AUC值为0.887,敏感度92.3%。结论:PCOS不孕女性患者INHB、AMH及bFSH水平异常,其用于预测卵巢储备功能有一定价值,三者联合可以有效提高对于患者卵巢储备功能预测价值。Objective:To explore the evaluative values of the levels of inhibin B(INHB),anti-Mullerian hormone(AMH),and basal follicle stimulating hormone(bFSH)of women with infertility induced by polycystic ovary syn-drome(PCOS)for their ovarian reserve function.Methods:A total of 87 women with PCOS induced infertility(in study group)and 53 healthy women(in control group)between October 2019 and October 2020 were collcted respectively.The levels of serum INHB,AMH,and bFSH of the women in the two groups were detected.According to the number of retrieved oocytes,the women in the study group were divided into group A(women with ovarian low re-sponse)and group B(women with normal ovarian response).And the levels of serum INHB,AMH,and bFSH of the women for evaluating their ovarian reserve function was analyzed.Results:The levels of serum INHB(149.78±36.92 pg/m)and AMH(10.94±3.21 ng/m)of the women in the study group were significantly higher than those(96.85±31.29 pg/ml and 3.29±0.95 ng/ml)of the women in the control group.The bFSH level(13.08±3.41 IU/L)of the women in the study group was significantly lower than that(16.29±4.74 IU/L)of the women in the control group.The serum INHB and AMH levels of the women in group A were significantly higher than those of the women in group B,but the bFSH level of the women in group A was significantly lower(all P<0.05).Pearson correlation analysis showed that in the study group,the serum INHB level of the women was positively correlated with their AMH level(r=0.516)and was negatively correlated with their bFSH level(r=-0.637),and the AMH level of the women was negatively correlated with their BFSH level(r=-0.453)(all P<0.05).The receiver operator characteristic curve showed that the area under the curve(AUC)of the serum INHB,AMH,and bFSH levels of the women for evaluating their ovarian reserve function were 0.726,0.774,and 0.695,respectively,and the AUC of the combined detections of serum INHB,AMH,and bFSH levels of the women for evaluating their ovarian reserve function was 0.887,with

关 键 词：多囊卵巢综合征 不孕 卵巢储备功能 抑制素B 早卵泡期抗苗勒氏管激素 基础卵泡刺激素 评估 

分 类 号：R711.75[医药卫生—妇产科学] R711.6[医药卫生—临床医学]