米非司酮不同给药方式联合米索前列醇治疗瘢痕子宫早期妊娠人工流产效果  

Effct of different doses of mifepristone combined with misoprostol for abortion of early pregnancy of women with scarred uterus

作　　者：冯艳丽 刘慧丽 FENG Yanli;LIU Huili(Huangdao District Second Hospital of Traditional Chinese Medicine,Qingdao,Shandong Province,266499;Henan Provincial Peoples Hospital,Zhengzhou University Peoples Hospital,Zhengzhou)

机构地区：[1]青岛市黄岛区第二中医医院,266499 [2]河南省人民医院郑州大学人民医院

出　　处：《中国计划生育学杂志》2023年第3期606-608,613,共4页Chinese Journal of Family Planning

摘　　要：目的:探讨米非司酮不同给药方式联合米索前列醇对瘢痕子宫早期妊娠流产效果。方法回顾性分析2017年9月-2020年9月本各院收治的瘢痕子宫早期妊娠流产104例临床资料,根据治疗方式的不同分为顿服组53例[米非司酮顿服200mg,服药后第3日早口服米索前列醇0.6mg],分服组51例[口服米非司酮75mg,12h后25mg连服2天,第3d服用米索前列醇0.6mg]。比较两组流产效果及不良反应。结果:分服组完全流产率(94.1%)高于顿服组(81.1%)(P<0.05),月经复潮时间两组(40.2±3.9d、39.5±3.6d)无差异(P>0.05),分服组孕囊组织排出时间(3.1±1.1 h)及阴道流血时间(8.1±4.3d)均短于顿服组(4.6±1.4 h、12.2±4.5d)(P<0.05),不良反应总发生率顿服组与分服组(54.7%、37.7%)无差异(P>0.05)。结论:米非司酮连续给药配合米索前列醇应用,可提高完全流产率,缩短孕囊组织排出时间、阴道流血时间。Objective:To investigate the effect of different doses of mifepristone combined with misoprostol for abortion of early pregnancy of women with scarred uterus.Methods:The clinical data of 104 women with scarred uterus and abortion during the first trimester of pregnancy from September 2017 to September 2020 were collected retrospectively.According to the difference of treatment schemes,these women were divided into two groups.53 women in group A were given mifepristone(200mg),and then were given oral misoprostpl(0.6mg)in the morning after three days of oral mifepristone.51 women in group B were given oral mifepristone(75mg),after 12h of that,oral mifepristone(25mg)per day for two days,and then were given oral misoprostol(0.6mg)on the third day.The abortion effect and the incidence of adverse reactions of the women were compared between the two groups.Results:The completely abortion rate(94.1%)of the women in group B was significantly higher than that(81.1%)of the women in group A(P<0.05).There was no significant difference in the menstrual recovery time(40.2±3.9d vs.39.5±3.6d)of the women between the two groups(P>0.05).The expel time of gestational sac(3.1±1.1 h)and the vaginal bleeding time(8.1±4.3d)of the women in group B were significantly shorter than those(4.6±1.4 h and 12.2±4.5d)of the women in groupA(P<0.05).There was no significant difference in the total incidence of adverse reactions(54.7%vs.37.7%)of the women between group A and group B(P>0.05).Conclusion:Mifepristone used continually combined with misoprostol for a-bortion of the women with scarred uterus can significantly improve their complete abortion rate,and can shorten their expel time of gestational sac and vaginal bleeding time.

关 键 词：早期妊娠 瘢痕子宫 流产 米非司酮 米索前列醇 不同给药方法 效果 

分 类 号：R169.42[医药卫生—公共卫生与预防医学]