妊娠期糖尿病孕妇血清AHSG、PAPP-A水平及与妊娠结局关系  

Levels of serum human AHSG and pregnancy associated plasma protein A of pregnant women with gestational diabetes mellitus and their correlation with the pregnancy outcomes

作　　者：吴蕾 韩研 吕骥 郭莹 WU Lei;HAN Yan;LV Ji;GUO Ying(Qinhuangdao Maternal and Child Health Care Hospital,Hebei Province,066000;Qinhuangdao First Hos pital)

机构地区：[1]河北省秦皇岛市妇幼保健院,066000 [2]河北省秦皇岛市第一医院

出　　处：《中国计划生育学杂志》2023年第3期628-631,共4页Chinese Journal of Family Planning

摘　　要：目的:分析妊娠期糖尿病(GDM)孕妇血清胎球蛋白A(AHSG)、妊娠相关蛋白-A(PAPP-A)水平及与妊娠结局关系。方法选择2018年2月-2021年2月在本院确诊为GDM患者102例(GDM组),分娩正常的健康孕妇102例为对照组。酶联免疫吸附法检测血清AHSG水平,免疫荧光法检测血清PAPP-A水平;受术者工作特征曲线(ROC)分析血清AHSG、PAPP-A预测GDM发生价值,Pearson分析血清AHSG、PAPP-A水平与妊娠结局的相关性。结果:GDM组血清AHSG水平(263.07±53.28μg/L)高于对照组(173.94±47.51μg/L),PAPP-A水平(21.42±1.47 ng/ml)低于对照组(26.05±1.39 ng/ml),GDM组中发生不良妊娠结局者血清AHSG水平高于妊娠结局良好者,PAPP-A水平低于妊娠结局良好者,且血清AHSG水平与不良妊娠结局呈正相关(r=0.215),PAPP-A水平与不良妊娠结局呈负相关(r=-0.757)(均P<0.05)。ROC分析,血清AHSG、PAPP-A及联合检测预测GDM的曲线下面积分别为0.784、0.724、0.844。结论:GDM孕妇血清AHSG和PAPP-A水平发生异常,且水平与不良妊娠结局具有相关性,检测2项指标对预测GDM发生有一定临床价值,为临床及时干预提供指导。Objective:To analyze the levels of serum human AHSG and pregnancyassociated plasma protein-A(PAPP-A)of pregnant women with gestational diabetes mellitus,and to study their correlation with the pregnancy outcomes of the women.Methods:A total of 102 pregnant women with GDM were selected in research group,102 healthy pregnant women were selected in control group between February 2018 and February 2021.The level of serum AHSG was detected by enzyme-linked immunosorbent assay,and the level of serum PAPP-A was detected by immunofluorescence assay.The predictive value of the serum AHSG and PAPP-A levels of the women for GDM was analyzed by receiver operating characteristic(ROC)curve.The correlation between the levels of serum AHSG and PAPP-A of the women and their pregnancy outcomes was analyzed by Pearson analysis.Results:The level of serum AHSG(263.07±53.28 pg/L)of the women in the research group was significantly higher than that(173.94±47.51μg/L)of the women in the control group,and the level of PAPP-A(21.42±1.47 ng/ml)of the women in the research group was significantly low-er than that(26.05±1.39 ng/ml)of the women in the control group.In the research group,the level of serum AHSG of the women with adverse pregnancy outcomes was significantly higher than that of the women with normal pregnancy outcomes,and the level of PAPP-A of the women with adverse pregnancy outcomes was significantly lower.The level of serum AHSG level of the women in the research group was positively correlated with their adverse pregnancy out-comes(r=0.215),and the PAPP-A level of the women in the research group was negatively correlated with their ad-verse pregnancy outcomes(r=-0.757)(all P<0.05).ROC analysis showed that the area under the curve of the serum AHSG level,the PAPP-A level,and the combined levels of AHSG and PAPP-A of the women for predicting their GDM were 0.784,0.724,and 0.844,respectively.Conclusion:The levels of serum AHSG and PAPP-A of the preg-nant women with GDM are abnormal,and which are correlated with the adverse

关 键 词：妊娠期糖尿病 胎球蛋白A 妊娠相关蛋白-A 妊娠结局 

分 类 号：R714.256[医药卫生—妇产科学]