子痫前期患者HMGB1、ADMA水平变化及与螺旋动脉管壁厚度及管腔面积的相关性  

Changes of the levels of high mobility group protein box-1 and asymmetric dimethylarginine of pregnant women with pre-eclampsia and their correlation with the wall thickness and lumen area of the placental spiral artery

作　　者：宋丹丹 SONG Dandan(Luoyang City Maternal and Child Health Care Hospital,Henan Province,471000)

机构地区：[1]河南省洛阳市妇幼保健院,471000

出　　处：《中国计划生育学杂志》2023年第3期632-635,共4页Chinese Journal of Family Planning

摘　　要：目的:探讨子痫前期患者高纤移率族蛋白B1(HMGB1)、不对称性的二甲基精氨酸(ADMA)水平及与螺旋动脉管壁厚度及管腔面积关系。方法:选取本院2019年1月-2021年6月收治子痫前期患者72例临床资料,分为重度子痫前期组(n=37例)、轻度子痫前期组(n=35例),健康孕妇作为对照组(n=35例)。酶联免疫吸附法检测3组血HMGB1、ADMA表达水平,电子显微镜观察并检测孕妇螺旋动脉管厚和管腔面积,分析子痫前期孕妇HMGB1、ADMA水平与壁厚及管腔面积的相关性。结果:血HMGB1、HMGB1表达水平重度子痫前期组(24.58±4.36ng/ml、5.03±3.24umol/ml)、轻度子痫前期组(17.41±7.41ng/ml、2.74±0.40umol/ml),对照组(10.24±2.53ng/ml、1.87±3.02)umol/ml)依次降低;重度子痫前期组胎盘螺旋动脉壁厚以及管腔的面积分别为(118.14±9.03um、138.47±28.41um^(2)),轻度子痫前期组(107.21±8.40um、156.21±26.74um^(2)),对照组(102.08±8.57um、190.53±26.59um^(2))存在差异(均P<0.05)。子痫前期孕妇HMGB1、ADMA与螺旋动脉管壁厚度呈负相关(r=-0.631、-0.655,P<0.001),与螺旋动脉管腔面积呈正相关(r=0.715、0.693,P<0.001)。结论:HMGB1和ADMA表达水平可以作为评价子痫前期患者病情程度的指标,该两项指标可能参与了子痫前期患者胎盘螺旋动脉重铸的障碍过程,为子痫前期的发病机制提供一定理论支持。Objective:To investigate the levels of high mobilty group protein box-1(HMGB1)and asymmetric dimeth-ylarginine(ADMA)of pregnant women with preeclampsia and their correlation with the wall thickness and lumen area of the placental spiral artery of the women.Methods:The clinical data of 72 pregnant women with preeclampsia from January 2019 to June 2021 were selected in this study.These women were divided into 37 cases with severe preeclampsia in group A and 35 cases with mild preeclampsia in group B according to the soverity of preeclampsia.35 normal healthy pregnant women during the same period were selected in group C.Enzyme-linked immunosorbent assay(ELISA)was used to detect the expression levels of serum HMGB1 and ADMA of the women in the three groups.Electron microscopy was used to observe and measure the wall thickness and lumen area of the placental spiral artery of the women in the three groups.The correlation between the levels of HMGB1 and ADMA of the women with pre-eclampsia and the wall thickness and lumen area of their placental spiral artery was analyzed.Results:The expression levels of serum HMGB1 and HMGB1 of the women in group A(24.58±4.36ng/ml and 5.03±3.24umol/m),in group B(17.41±7.41ng/ml and 2.74±0.40umol/ml),and in group C(10.24±2.53ng/ml and 1.87±3.02)umol/ml)had decreased gradually.The wall thickness and lumen area of placental spiral artery of the women in group A(118.14±9.03.um and 138.47±28.41um^(2))had significantly different from those(107.21±8.40um and 156.21±26.74um^(2))of the women in group B,and those(102.08±8.57um and 190.53±26.59um^(2))of the women in group C(all P<0.05).The levels of serum HMGB1 and ADMA of the pregnant women with preeclampsia were negatively correlated with their placental spiral artery wall thickness(r=-0.631,-0.655,P<0.001),and were positively correlated with their placental spiral artery lumen area(r=0.715,0.693,P<0.001).Conclusion:The expression levels of HMGB1 and ADMA of the women can be used as the indicators to evaluate the severity of their

关 键 词：子痫前期 病情程度 高纤移率族蛋白B1 不对称性二甲基精氨酸 螺旋动脉管壁厚度 管腔面积 相关性 胎盘螺旋动脉重铸 

分 类 号：R714.244[医药卫生—妇产科学]