尿酸对老年膝骨关节炎病人软骨GLUT9、URAT1表达的影响  

Effects of uric acid on the expression of GLUT9 and URAT1 of cartilage in elderly patients with knee osteoarthritis

作　　者：张雪梅[1] 王忠丽[2] 王超[3] 黄腾[4] 张凯 聂倩[2] 宋光耀[3] ZHANG Xue-mei;WANG Zhong-li;WANG Chao;HUANG Teng;ZHANG Kai;NIE Qian;SONG Guang-yao(Department of Rheumatology and Immunology,Hebei Gerneral Hospital,Shijiazhuang 050051,China;Medical Examination Center,Hebei Gerneral Hospital,Shijiazhuang 050051,China;Key Laboratory of Metabolic Diseases,Hebei Gerneral Hospital,Shijiazhuang 050051,China;Department of Orthopaedics,Hebei Gerneral Hospital,Shijiazhuang 050051,China)

机构地区：[1]河北省人民医院风湿免疫科,河北省石家庄市050051 [2]河北省人民医院体检中心,河北省石家庄市050051 [3]河北省人民医院代谢病重点实验室,河北省石家庄市050051 [4]河北省人民医院骨科,河北省石家庄市050051

出　　处：《实用老年医学》2023年第3期287-290,共4页Practical Geriatrics

摘　　要：目的探讨老年膝骨关节炎病人血清UA水平与软骨组织中UA转运蛋白的相关性。方法收集2018~2019年就诊于河北省人民医院骨科的老年膝骨关节炎(KOA)病人30例。以所有入选者UA中位数水平(254.6μmol/L)将病人分为血清UA<254.6μmol/L组(A组)和UA≥254.6μmol/L组(B组),检测并比较2组软骨组织中葡萄糖易化转运蛋白9(GLUT9)和尿酸盐转运蛋白1(URAT1)的mRNA和蛋白的表达水平。结果与B组相比,A组病人的体质量、BMI较小,VAS评分较低,差异均有统计学意义(P<0.05)。Pearson相关分析显示,VAS评分与UA水平呈正相关(r=0.396,P<0.05)。B组病人关节软骨中GLUT9、URAT1的mRNA和蛋白表达水平均较A组明显升高,差异有统计学意义(P<0.05)。结论UA水平的升高可能通过增加软骨中GLUT9及URAT1蛋白的表达,使软骨细胞内UA水平升高,诱导软骨细胞氧化损伤,从而参与KOA的发病。Objective To investigate the correlation between serum uric acid(UA)level and the expression of UA transporter protein of cartilage tissue in the elderly patients with knee osteoarthritis(KOA).Methods A totoal of 30 elderly patients with KOA in the Department of Orthopedics,Hebei General Hospital from January 2018 to December 2019 were enrolled.According to the median level of UA,the patients were divided into UA<254.6μmol/L group(group A)and UA≥254.6μmol/L group(group B).The expression levels of glucose transporter 9 polypeptide(GLUT9)and urate transporter 1(URAT1)in cartilage tissue in the two groups were detected and compared.Results The levels of weight and body mass index(BMI),and visual analogue scale(VAS)score in group A were significantly lower than those in group B(P<0.05).Pearson analysis showed that VAS score was positively correlated with UA level(r=0.396,P<0.05).Compared with group A,the expression levels of GLUT9 and URAT1 mRNA and protein were significantly increased in group B(P<0.05).Conclusions The increase of UA level may increase the expression of GLUT9 and URAT1 protein in cartilage and the level of UA in chondrocytes,which induces the oxidative damage of chondrocytes,thereby participating in the pathogenesis of KOA.

关 键 词：尿酸 膝骨关节炎 葡萄糖易化转运蛋白9 尿酸盐转运蛋白1 

分 类 号：R681[医药卫生—骨科学]