社区老年人骨骼肌质量指数与TG/HDL-C的相关性研究  

Correlation between skeletal muscle index and triglyceride/high density lipoprotein cholesterol ratio in community-dewlling elderly adults

作　　者：底佳倩 杨凯悦 和丽丽[2] 郭艺芳[2] DI Jia-qian;YANG Kai-yue;HE Li-li;GUO Yi-fang(Graduate School of North China University of Science and Technology,Tangshan 063210,China;Department of Geriatric Cardiology,Hebei General Hospital,Shijiazhuang 050051,China)

机构地区：[1]华北理工大学研究生学院,河北省唐山市063210 [2]河北省人民医院老年心内科,河北省石家庄市050051

出　　处：《实用老年医学》2023年第3期291-294,共4页Practical Geriatrics

摘　　要：目的研究社区老年人四肢骨骼肌质量指数(appendicular skeletal muscle index,ASMI)和血清TG与HDL-C比值(TG/HDL-C)的相关性。方法收集健康体检老年受试者(年龄≥65岁)中符合纳入标准且相关临床资料齐全者共192例,整理受试者的基线资料、血液学指标,将体检当天受试者通过人体成分分析仪测得的ASMI按照三分位法分为3组:<8.41为低分位组(n=64),8.41~9.16为中分位组(n=64),>9.16为高分位组(n=64)。比较3组的基线资料、生化指标和人体成分指标水平,并通过Spearman相关分析研究ASMI与相关变量之间的相关性,采用多因素Logistic回归分析ASMI的影响因素。结果在社区老年人中,随着ASMI的增加,3组TG/HDL-C也增加,差异有统计学意义(P=0.004)。Spearman相关分析显示,ASMI与男性、SBP、DBP、基础代谢量、肌肉量、腰臀比、TG/HDL-C和ALT均呈正相关(P<0.05)。多因素Logistic回归分析显示:性别(OR=0.130,95%CI:0.027~0.635)、TG/HDL-C(OR=0.575,95%CI:0.332~0.996)、肌肉量(OR=0.609,95%CI:0.485~0.766)、基础代谢量(OR=1.011,95%CI:1.001~1.021)是ASMI的独立影响因素。结论TG/HDL-C有助于预测老年人ASMI的下降趋势,对筛查社区老年人可疑肌少症病人具有一定临床意义。Objective To investigate the correlation between appendicular skeletal muscle index(ASMI)and triglyceride/high density lipoprotein cholesterol ratio(TG/HDL-C)in the community-dewlling elderly adults.Methods A total of 192 elderly subjects(aged≥65 years old)who met the inclusion criteria and completed relevant clinical data were enrolled in this study.The baseline data and the levels of hematological indicators were collected.According to ASMI measured by the body composition analyzer on the day of physical examination,all the subjects were divided into the low quantile group(ASMI<8.41),middle quantile group(ASMI=8.41-9.16)and high quantile group(ASMI>9.16),with 64 cases in each group.The baseline data and the levels of biochemical and body composition indicators were compared among the three groups.Spearman correlation analysis was used to analyze the correlations between ASMI and related variables.Multivariate Logistic regression was used to analyze the influencing factors of ASMI.Results Among the elderly in the community,with the increase of ASMI,TG/HDL-C also increased significantly in the three groups(P<0.05).Spearman correlation analysis showed that ASMI was positively correlated with gender,systolic blood pressure(SBP),diastolic blood pressure(DBP),basal metabolic volume,muscle mass,waist-to-hip ratio(WHR),TG/HDL-C and alanine aminotransferase(ALT).Multivariate Logistic regression analysis showed that gender(OR=0.130,95%CI:0.027-0.635),TG/HDL-C(OR=0.575,95%CI:0.332-0.996),muscle mass(OR=0.609,95%CI:0.485-0.766)and basal metabolism volume(OR=1.011,95%CI:1.001-1.021)were the independent influencing factors of ASMI.Conclusions TG/HDL-C is helpful to predict the declining trend of ASMI in the elderly,and has clinical significance for screening elderly patients with suspected sarcopenia in the community.

关 键 词：老年人 肌少症 骨骼肌质量指数 甘油三酯/高密度脂蛋白胆固醇比值 

分 类 号：R336[医药卫生—人体生理学]