25-羟维生素D_(3)和病毒感染与反复喘息婴幼儿哮喘预测指数的相关性研究  

Association of 25-hydroxyvitamin D_(3)and viral infection with the predictive index of asthma in infants with recurrent wheezing

作　　者：任天思 郭秀玲[1] 李然 王艳录 杨磊 REN Tiansi;GUO Xiuling;LI Ran;WANG Yanlu;YANG Lei(Department of Pediatrics,Handan Central Hospital,Handan,Hebei 056001,China)

机构地区：[1]邯郸市中心医院儿内科,河北邯郸056001

出　　处：《徐州医科大学学报》2023年第2期128-133,共6页Journal of Xuzhou Medical University

基　　金：河北省医学科学研究课题(20220554)。

摘　　要：目的探究25-羟维生素D_(3)(25-OH-D_(3))、病毒感染与反复喘息婴幼儿哮喘预测指数(API)的相关性。方法选取2020年4月—2021年4月邯郸市中心医院儿科住院的反复喘息婴幼儿106例作为研究对象,根据入院时API分为API阳性组(n=65)和API阴性组(n=41),比较2组一般资料、血清25-OH-D_(3)水平、反复喘息前病毒感染率、感染病毒种类、外周血嗜酸粒细胞(B-Eos)计数、血清总免疫球蛋白E(IgE)水平,通过Logistic多因素回归模型分析反复喘息婴幼儿API阳性的影响因素,采用Spearman相关系数模型分析血清25-OH-D_(3)水平、反复喘息前病毒感染率与B-Eos计数、血清总IgE的相关性,所有患儿均给予对症治疗,治疗12周后统计预后情况,比较不同预后患儿入院时血清25-OH-D_(3)水平、反复喘息前病毒感染率、API阳性率,并分析各指标预测患儿预后的效能。结果API阳性组血清25-OH-D_(3)水平低于API阴性组,反复喘息前病毒感染率、B-Eos计数、血清总IgE水平均高于API阴性组(P<0.05);血清25-OH-D_(3)水平、病毒感染、B-Eos计数、血清总IgE水平均与反复喘息婴幼儿API阳性存在显著关联性(P<0.05);API阳性组血清25-OH-D_(3)水平与B-Eos计数、血清总IgE水平呈负相关,反复喘息前病毒感染率与B-Eos计数、血清总IgE水平呈正相关(P<0.05);治疗12周后,持续喘息患儿入院时血清25-OH-D_(3)水平低于喘息消失患儿,反复喘息前病毒感染率、API阳性率高于喘息消失患儿(P<0.05);入院时血清25-OH-D_(3)水平、病毒感染、API阳性预测持续喘息患儿预后为持续喘息的曲线下面积(AUC)均>0.7,联合预测的AUC最大,为0.907。结论25-OH-D_(3)和病毒感染与反复喘息婴幼儿API存在显著关联性,且在预测患儿预后方面具有较高参考价值。Objective To investigate the association of 25-hydroxyvitamin D_(3)(25-OH-D_(3))and viral infection with asthma predictive index(API)in infants with recurrent wheezing.Methods A total of 106 infants with recurrent wheezing who were admitted to Department of Pediatrics,Handan Central Hospital from April 2020 to April 2021 were selected.According to the presence of API at admission,they were divided into two groups:an API-positive group(n=65)and an API-negative group(n=41).Both groups were compared for general information,serum 25-OH-D_(3)level,the viral infection rate before recurrent wheezing,the type of infected virus,peripheral blood eosinophil(B-Eos)count and serum total immunoglobulin E(IgE)level.The influencing factors of API positive in infants with recurrent wheezing were analyzed by Logistic multi-factor regression model.The correlation between serum 25-OH-D_(3)level,the viral infection rate of recurrent wheezing and B-Eos count and total serum IgE was analyzed by Spearman correlation coefficient model.All children were given symptomatic treatment,and the prognosis was recorded after 12 weeks of treatment.Infants with different prognosis were compared for their 25-OH-D_(3)level,the viral infection rate of recurrent wheezing,and API positive rateat admission.The efficiency of each indicator for predicting the prognosis of infants was analyzed.Results The API-positive group showed decreases in serum 25-OH-D_(3)level,the viral infection rate before recurrent wheezing,B-Eos count,and total serum IgE level,compared with the API-negative group(P<0.05).Serum 25-OH-D_(3)level,viral infection,B-Eos count,and total serum IgE level were significantly associated with API positive in infants with recurrent wheezing(P<0.05).For the API-positive group,serum 25-OH-D_(3)level was negatively correlated with B-Eos count and total serum IgE level,while the viral infection rate before recurrent wheezing was positively correlated with B-Eos count and total serum IgE level(P<0.05).After 12 weeks of treatment,infants with persis

关 键 词：婴幼儿 反复喘息 哮喘预测指数 25-羟维生素D_(3) 病毒感染 

分 类 号：R725.6[医药卫生—儿科]