代谢重编程:单核/巨噬细胞训练免疫参与动脉粥样硬化的新机制  

Metabolic reprogramming:a novel mechanism of monocyte/macrophage trained immunity in atherosclerosis

作　　者：杨尧 闫明静 徐昆 孙升辉 李汶霖 窦琳[1] 黄秀清[1] 唐蔚青[1] 黎健[1,2] 沈涛[1,2] YANG Yao;YAN Mingjing;XU Kun;SUN Shenghui;LI Wenlin;DOU Lin;HUANG Xiuqing;TANG Weiqing;LI Jian;SHEN Tao(The Key Laboratory of Geriatrics,Beijing Institute of Geriatrics,Institute of Geriatric Medicine,Chinese Academy of Medical Sciences,Beijing Hospital/National Center of Gerontology of National Health Commission,Beijing 100730,China;Peking University Fifth School of Clinical Medicine,Beijing 100730,China)

机构地区：[1]北京医院国家老年医学中心、国家卫生健康委北京老年医学研究所、国家卫生健康委老年医学重点实验、室中国医学科学院老年医学研究院,北京市100730 [2]北京大学第五临床医学院,北京市100730

出　　处：《中国动脉硬化杂志》2023年第3期199-204,244,共7页Chinese Journal of Arteriosclerosis

基　　金：国家自然科学基金项目(81770228、81600618和81770858)。

摘　　要：动脉粥样硬化是血管的慢性炎症性疾病,单核/巨噬细胞的异常活化与动脉粥样硬化的发生发展密切相关。近期研究发现单核/巨噬细胞可以通过训练免疫发生代谢重编程,促进炎症反应,加快动脉粥样硬化的进展,并可以导致心血管意外事件的发生。文章综述了单核/巨噬细胞代谢重编程在训练免疫发生中的作用和机制,可能为动脉粥样硬化的防治提供新的治疗靶点和方法。Atherosclerosis is a chronic inflammatory disease of artery.Abnormal activation of monocytes/macrophages is closely related to the development of atherosclerosis.Recent studies have found that monocytes/macrophages can undergo metabolic reprogramming by trained immunity,promote inflammatory responses,which accelerate the progression of atherosclerosis and increase cardiovascular incidents.In this review,we discuss the function and mechanisms of metabolic reprogramming of monocytes/macrophages in the trained immunity,which may provide new therapeutic targets and methods for the prevention and treatment of atherosclerosis.

关 键 词：动脉粥样硬化 训练免疫 代谢重编程 表观遗传重编程 

分 类 号：R54[医药卫生—心血管疾病]