免疫细胞在动脉粥样硬化中的代谢重编程现象  

Metabolic reprogramming of immune cells in atherosclerosis

作　　者：徐芳芷 窦琳[1] 沈涛[1] 马佳睿 左惠演 刘进[2] 黎健[1] 黄秀清[1] XU Fangzhi;DOU Lin;SHEN Tao;MA Jiarui;ZUO Huiyan;LIU Jin;LI Jian;HUANG Xiuqing(The Key Laboratory of Geriatrics,Beijing Institute of Geriatrics,Institute of Geriatric Medicine,Chinese Academy of Medical Sciences,Beijing Hospital/National Center of Gerontology of National Health Commission,Beijing 100730,China;Beijing Key Laboratory of Gene Resource and Molecular Development,College of Life Sciences,Beijing Normal University,Beijing 100875,China)

机构地区：[1]北京医院国家老年医学中心、国家卫生健康委北京老年医学研究所、国家卫生健康委老年医学重点实验室、中国医学科学院老年医学研究所,北京市100730 [2]抗性基因资源与分子发育北京市重点实验室、北京师范大学生命科学学院,北京市100875

出　　处：《中国动脉硬化杂志》2023年第3期218-224,260,共8页Chinese Journal of Arteriosclerosis

基　　金：国家自然科学基金项目(81770858、81600618和81770228)。

摘　　要：动脉粥样硬化是以动脉血管壁脂质沉积为特征的慢性炎症性疾病,其中固有免疫细胞和适应性免疫细胞都参与疾病进程并发挥不同作用。这些免疫细胞的代谢重编程通过调节免疫细胞表型和功能进而调控疾病的进展。文章综述了动脉粥样硬化病程相关的主要免疫细胞的代谢途径变化,并对这些免疫细胞间代谢重编程的种类和机制进行总结。Atherosclerosis is a chronic inflammatory disease characterized by lipid deposition in the arterial vessel wall, in which both innate and adaptive immune cells are involved in the disease process and play different roles. Metabolic reprogramming of these immune cells modulates disease progression by modulating immune cell phenotype and function. This article reviews the metabolic pathway changes of major immune cells associated with the course of atherosclerosis, and summarizes the types and mechanisms of metabolic reprogramming among these immune cells.

关 键 词：动脉粥样硬化 固有免疫细胞 适应性免疫细胞 代谢重编程 

分 类 号：R541.4[医药卫生—心血管疾病]