m^(6)A甲基化修饰在动脉粥样硬化中的作用  

The role of m^(6)A methylation modification in atherosclerosis

作　　者：李胜昆 程道宾[1] LI Shengkun;CHENG Daobin(Department of Neurology,The First Affiliated Hospital of Guangxi Medical University,Nanning,Guangxi 530000,China)

机构地区：[1]广西医科大学第一附属医院神经内科,广西壮族自治区南宁市530021

出　　处：《中国动脉硬化杂志》2023年第3期271-276,共6页Chinese Journal of Arteriosclerosis

基　　金：国家自然科学基金项目(82060248);广西研究生教育创新计划项目(YCSW2022212)。

摘　　要：N6-甲基嘌呤(m^(6)A)是真核生物中最常见的转录后RNA修饰类型,涉及多种类型RNA。m^(6)A甲基化修饰是动态可逆的,主要由多种酶和蛋白进行调控,包括甲基转移酶、去甲基化酶和m^(6)A相关结合蛋白。动脉粥样硬化是心脑血管疾病的主要原因。近期研究发现m^(6)A甲基化修饰与动脉粥样硬化密切相关。该文总结了目前对m^(6)A甲基化修饰机制的认识,并阐述了与动脉粥样硬化相关细胞中m^(6)A甲基化修饰的机制及最新进展,为动脉粥样硬化的诊断和防治提供新靶点。N6-methylpurine(m^(6)A)is the most common type of post-transcriptional RNA modification in eukaryotes,involving many types of RNA.m^(6)A methylation modification is dynamic and reversible and is mainly regulated by a variety of enzymes and proteins,including methyltransferase,demethylase and m^(6)A-related binding proteins.Atherosclerosis is the main cause of cardiovascular and cerebrovascular diseases.Recent studies have found that m^(6)A methylation is closely related to atherosclerosis.This paper summarizes the current understanding of the mechanism of m^(6)A methylation modification,and reviews the mechanism and latest progress of m^(6)A methylation modification in atherosclerosis-related cells,so as to provide a new target for the diagnosis,prevention and treatment of atherosclerosis.

关 键 词：m^(6)A甲基化修饰 甲基转移酶 去甲基化酶 m^(6)A结合蛋白 动脉粥样硬化 

分 类 号：R543[医药卫生—心血管疾病]