心肌梗死后抑郁动物模型的研究进展  

Review of constructing animal models of depression after myocardial infarction

作　　者：孙怿泽 史金玉 齐鑫 曹俊岭 王哲义 SUN Yi-ze;SHI Jin-yu;QI Xin;CAO Jun-ling;WANG Zhe-yi(Qilu Hospital(Qingdao),Shandong University,Qingdao Shandong 266035,China;The Third Affiliated Hospital of Beijing University of Chinese Medicine,Beijing 100029,China;Oriental Hospital,Beijing University of Chinese Medicine,Beijing 100078,China)

机构地区：[1]山东大学齐鲁医院(青岛),山东青岛266035 [2]北京中医药大学第三附属医院,北京100029 [3]北京中医药大学附属东方医院,北京100078

出　　处：《中国药理学通报》2023年第3期401-406,共6页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金青年项目(No 82205032)。

摘　　要：心肌梗死后抑郁(depression after myocardial infarction,DAMI)临床发病率较高,对患者的身心健康造成较大危害,但发病机制尚不清楚。采用能模拟人类DAMI发病原因和生物学反应的动物模型进行基础研究,是探索疾病机制的有效途径。该文将动物选择、模型选择、模型制备、行为学评价等建模过程中存在的问题进行总结和思考,以期为DAMI的模型研究提供参考。The incidence of depression after myocardial infarction(DAMI)is high,causing significant harm to the patients’physical and mental health,but the pathogenesis is unknown.Establishing animal models which simulate the pathogenesis of DAMI in humans is an effective way to explore the mechanism of the disease.In this paper,problems existing in the modeling process,such as animal selection,model selection,model preparation and behavioral evaluation,are summarized and considered in order to provide reference for DAMI model research.

关 键 词：心肌梗死后抑郁 动物模型 复合模型 行为学测试 环境应激 综述 

分 类 号：R332[医药卫生—人体生理学] R363-332[医药卫生—基础医学] R542.22R749.42