三甲基氯化锡中枢神经毒性机制及防治研究进展  

Research progress on central neurotoxicity mechanism and prevention of trimethyltin chloride

作　　者：高于婷 蔡飞[2] GAO Yu-ting;CAI Fei(School of Pharmacy,Hubei University of Science and Technology,Xianning,Hubei 437100,China;Hubei Key Laboratory of Diabetes and Angiopathy,Hubei University of Science and Technology,Xianning,Hubei 437100,China)

机构地区：[1]湖北科技学院医学部药学院,湖北咸宁437100 [2]湖北科技学院糖尿病心脑血管病变湖北省重点实验室,湖北咸宁437100

出　　处：《中国药理学通报》2023年第3期414-419,共6页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助项目(No 81870576);湖北省高校优秀中青年科技创新团队项目(No T201921);湖北省教育厅项目(No BXLBX0805)。

摘　　要：三甲基氯化锡(trimethyltin chloride,TMT)是聚氯乙烯(polyvinyl chloride,PVC)塑料制品合成过程中所产生的一种剧毒副产物。它具有选择性中枢神经毒性作用,主要表现为诱导人和动物边缘神经系统的神经元死亡,尤其是海马神经元。TMT中毒后会出现癫痫、腹泻及学习记忆功能障碍等多种临床表现,严重者甚至出现昏迷或死亡。为了提高对TMT中枢神经毒性的认识,现对TMT中枢神经毒性的分子机制及治疗药物的研究进展进行综述,旨在为TMT中枢神经毒性的预防或治疗提供新的研究思路。Trimethyltin chloride is a highly toxic by-product produced during the process of synthesizing polyvinyl chloride plastics.It has specially central neurotoxicity,which is mainly manifested as inducing the death of neurons in human and animal central nervous system,especially hippocampal neurons.TMT poisoning can cause seizures,diarrhea,learning and memory impairment and other clinical manifestations,and even coma or death in severe cases.In order to better understand the role of TMT neurotoxicity in central nerve system,this paper reviews the research progress on both the molecular mechanism and therapeutic drugs of central neurotoxicity caused by TMT,thereby providing new ideas for the prevention and treatment of TMT-induced neurotoxicity.

关 键 词：三甲基氯化锡 毒性 中枢神经系统 炎症 氧化应激 凋亡 

分 类 号：R322.81[医药卫生—人体解剖和组织胚胎学] R329.25[医药卫生—基础医学] R364.5R349.1R595R916.3