基于数据挖掘研究中医药治疗艾滋病相关性腹泻的用药规律  

Based on Data Mining to Study the Rule of Traditional Chinese Medicine in the Treatment of AIDS-related Diarrhea

作　　者：王凯宁 蔡生兴 周佩 张慧丰 高宏杰[3] 赵玉凤[1,2] Wang Kaining;Cai Shengxing;Zhou Pei;Zhang Huifeng;Gao Hongjie;Zhao Yufeng(Institute of Basic Research in Clinical Medicine,China Academy of Chinese Medical Sciences,Beijing 100700,China;National Date Center of Traditional Chinese Medicine,China Academy of Chinese Medical Sciences,Beijing 100700,China;Institution of Information on Traditional Chinese Medicine,China Academy of Chinese Medical Sciences,Beijing 100700,China)

机构地区：[1]中国中医科学院中医临床基础医学研究所,北京100700 [2]中国中医科学院中医药数据中心,北京100700 [3]中国中医科学院中医药信息研究所,北京100700

出　　处：《世界科学技术-中医药现代化》2022年第11期4132-4139,共8页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：国家科学技术部国家重点研发计划项目(2017YFC1703503):病案首页数据采集与中医医疗质量评价系统的创新研究,负责人:赵玉凤;国家自然科学基金委员会面上项目(81674101):基于多示例多标记学习发现艾滋病方证效动态靶关系方法的研究,负责人:赵玉凤;中国中医科学院中医药创新骨干人才项目(Z0688):真实世界中医临床大数据方法学研究,负责人:赵玉凤。

摘　　要：目的 基于数据挖掘方法探讨中医药治疗艾滋病相关性腹泻的用药规律及特色,为临床治疗本病提供一些新思路,同时也为临床用药研究提供参考。方法 (1)采用Excel表格对艾滋病相关性腹泻处方数据中的中药、药味类别、性味、归经情况进行描述性分析;(2)采用数据挖掘软件IBM SPSS Modeler 18.0的Apriori算法对高频中药进行关联规则分析;(3)采用IBM SPSS Statistics 26.0统计软件对频次最高的30种药物进行聚类分析。结果 筛选出436个病例,处方436首,共有中药279味,所有中药使用频次共计5527次,其中白术、甘草、茯苓、党参、山药使用次数最多,药物功效分类以补虚药、利水渗湿药最为常见,药味以甘、辛为主,药性以温/微温、平居多,药物归经以脾经最多,其次是心经、肺经;关联规则分析得到25种关联强度高的药物组合;聚类分析可将药物分为5类。结论 研究发现中医药治疗艾滋病相关性腹泻以补虚药、利水渗湿药为主,且多与药味甘、辛,药性温/微温、平,归脾经的药物进行搭配使用,其中茯苓-白术为最常用的药对,以新组方规律来看,更侧重于消积化滞、补气益血、滋阴生津。对中医药治疗艾滋病相关性腹泻的遣方用药,具有一定的参考意义。Objective Based on the method of data mining, it discusses the rules and characteristics of traditional Chinese medicine in the treatment of AIDS-related diarrhea, which provides some new ideas for the clinical treatment of this disease, and also provides references for clinical drug research. Methods(1)Use Excel table to perform descriptive analysis of the Chinese medicine, drug taste category, nature and taste, and menstrual status in the prescription data of AIDS-related diarrhea;(2)The Apriori algorithm of the data mining software IBM SPSS Modeler 18.0 is used to analyze the association rules of high-frequency Chinese medicine(3)Use IBM SPSS Statistics 26.0 statistical software to perform cluster analysis on the 25 most frequent drugs. Results 436 cases were screened, 436 prescriptions, and 279 Chinese medicines in total. All Chinese medicines were used 5527 times. Among them, Atractylodes macrocephala, licorice,Poria, Codonopsis, and Chinese yam were used the most frequently. The efficacy of the medicines was classified as tonic drugs, diuresis and dampness. Medicines are the most common. The main flavors of the medicines are sweet and pungent. The medicine properties are mostly warm/mild and flat. The meridian of the medicine is the most common in the spleen meridian, followed by the heart meridian and lung meridian. The association rule analysis yields 30 drug combinations with high correlation strength;the cluster analysis can divide the medicines into groups 5 categories,among them, the new components are 4 categories. Conclusion The study found that the treatment of AIDS-related diarrhea with traditional Chinese medicine is mainly tonic, diuresis and dampness medicine, and most of them are used in combination with medicines that are sweet, pungent, warm/mild, calm, and return to the spleen meridian. Among them, Poria-Atractylodes macrocephala is the most commonly used drug pair, from the law of the new component, more focused on consolidation, qi and blood, nourishing yin, which has certain reference si

关 键 词：艾滋病相关性腹泻 中医药 关联规则 聚类分析 用药规律 

分 类 号：R2-03[医药卫生—中医学]