音乐电针治疗抑郁症机制的实验研究进展  

Experimental Research Progress on the Mechanism of Music Electroacupuncture in the Treatment of Depression

作　　者：包宇[1] 耿少辉 陈宇坤 杨丽萍[4] Bao Yu;Geng Shaohui;Chen Yukun;Yang Liping(The First Clinical Medical College,Henan University of Chinese Medicine,Zhengzhou 450046,China;School of Life Sciences,Bejing University of Chinese Medicine,Bejing 100029,China;Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China;Basic Medical College,Henan University of Chinese Medicine,Zhengzhou 450046,China)

机构地区：[1]河南中医药大学第一临床医学院,郑州450046 [2]北京中医药大学生命科学院,北京100029 [3]上海中医药大学附属龙华医院,上海200032 [4]河南中医药大学基础医学院,郑州450046

出　　处：《世界科学技术-中医药现代化》2022年第11期4358-4365,共8页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：国家自然科学基金委员会面上项目(81973596):基于FTO介导胎盘m6A甲基化修饰探讨孕期恐伤肾致胎损的分子机制,负责人:杨丽萍。

摘　　要：音乐电针疗法将音乐声波转化为脉冲电流,作用于人体的感官和经穴,是音乐疗法与针刺疗法的有形结合,多项临床研究表明对抑郁症治疗效果良好,但目前作用机制尚未明晰。根据抑郁症发病的“单胺类神经递质假说”“兴奋性氨基酸假说”“细胞因子假说”“脑源性神经营养因子假说”“神经内分泌假说”“神经肽Y假说”,众多学者分别从上调海马区5-羟色胺(5-hydroxy tryptamine,5-HT)、去甲肾上腺素(Norepinephrine,NE)、多巴胺(Dopamine,DA);脑源性神经营养因子(Brain-derived neurotrophic factor,BDNF);下丘脑促甲状腺激素释放激素(Thyrotropin-releasing hormone,TRH);额叶、海马、下丘脑神经肽Y(Neuropeptide Y,NPY)表达水平;下调海马区白细胞介素-1β(Interleukin-1β,IL-1β)及白细胞介素-6(Interleukin-6,IL-6);兴奋性氨基酸谷氨酸(Glutamic acid,Glu)水平等角度揭示音乐电针治疗抑郁症的作用机制。现将音乐电针治疗抑郁症机制的实验研究进展及存在问题进行梳理归纳,以期为未来音乐电针治疗抑郁症的实验研究及临床研究提供一定的启示和思路。Music electroacupuncture transforms music sound wave into pulse current and acts on human senses and meridians. It is a tangible combination of music therapy and acupuncture. A number of clinical studies have shown that it has a good effect on depression, but the mechanism of action is not clear at present. According to the "monoamine neurotransmitter hypothesis", "excitatory amino acid hypothesis", "ytokine hypothesis", "brain-derived neurotrophic factor hypothesis", "neuroendocrine hypothesis" and "neuropeptide Y hypothesis" of depression, many scholars increased 5-HT, norepinephrine(NE) and dopamine(DA) in hippocampus respectively, brain derived neurotrophic factor(BDNF), hypothalamic thyroid stimulating hormone releasing hormone(TRH), the expression levels of neuropeptide Y(NPY) in frontal lobe, hippocampus and hypothalamus. Down regulation of interleukin-1 in hippocampus β(IL-1β) And interleukin-6(IL-6) and excitatory amino acid glutamate(Glu) levels to reveal the mechanism of music electroacupuncture in the treatment of depression. This paper summarizes the experimental research progress and existing problems of the mechanism of music electroacupuncture in the treatment of depression, in order to provide some enlightenment and ideas for the experimental and clinical research of music electroacupuncture in the treatment of depression in the future.

关 键 词：音乐电针 抑郁症 机制 综述 

分 类 号：R245.319[医药卫生—针灸推拿学]