植物多糖的抗肿瘤机制及其构效关系研究进展  

Research Progress on Antitumor Mechanism and Structure-activity Relationship of Plant Polysaccharides

作　　者：张桂凤 刘闯 刘光东 张仁堂[1] ZHANG Guifeng;LIU Chuang;LIU Guangdong;ZHANG Rentang(College of Food Science and Engineering,Shandong Agricultural University,Taian 271018,China;Shandong Land Rural Revitalization Group Co.,Ltd.,Jinan 251000,China)

机构地区：[1]山东农业大学食品科学与工程学院,山东泰安271018 [2]山东土地乡村振兴集团有限公司,山东济南251000

出　　处：《食品工业科技》2023年第7期428-437,共10页Science and Technology of Food Industry

基　　金：中央引导地方科技发展资金项目(YDZX2021071);2021年度山东省重点研发计划(乡村振兴科技创新提振行动计划)项目(2021TZXD011);德州市健康食品产业创新创业共同体;山东省土地发展集团有限公司科技项目。

摘　　要：植物多糖是天然多糖的主要来源之一,具有显著的抗肿瘤活性,在食品和医药领域有潜在的开发价值。本文系统总结了植物多糖的抗肿瘤作用机制和构效关系,重点从抑制肿瘤细胞生长、增强免疫调节、抑制肿瘤细胞侵袭和转移三个视角阐述了其抗肿瘤机制。并根据植物多糖的分子量、糖苷键类型和单糖组成、改性修饰和高级结构进一步剖析了其功能-结构关系。本文对近年来植物多糖抗肿瘤研究结论进行归纳整理,以期发现新的突破点,并为其进一步开发提供参考。Plant polysaccharides,one of the main sources of natural polysaccharides,has significant antitumor activity and are potentially exploitable in the field of food and medicine.This paper systematically summarizes the anti-tumor mechanism and structure-activity relationships of plant polysaccharides,focusing on three perspectives:Inhibition of tumor cell growth,enhancement of immune regulation,and inhibition of tumor cell invasion and metastasis.The functional-structural relationships of plant polysaccharides are further dissected based on their molecular weight,glycosidic bond types and monosaccharide composition,modified modifications and advanced structures.In this paper,the antitumor activity and structure-bioactivity relationships of plant polysaccharides are systematically summarized to provide a reference for discovering its new breakthroughs and further development.

关 键 词：植物多糖 抗肿瘤 作用机制 构效关系 

分 类 号：TS201.2[轻工技术与工程—食品科学] R285[轻工技术与工程—食品科学与工程]