外周血TXB2、NETs、6-K-PGF1α水平对创伤骨折患者深静脉血栓形成的评估价值  

Evaluation value of peripheral blood TXB2,NETs,6-K-PGF1αlevels on deep vein thrombosis in patients with traumatic fracture

作　　者：张林[1] 刘都[2] 王恒[1] 李星 ZHANG Lin;LIU Du;WANG Heng(Department of Orthopedics,Mianyang Orthopaedic Hospital,Mianyang Sichuan 621000,China;Department of Orthopedics,Mianyang Central Hospital,Mianyang Sichuan 621000,China)

机构地区：[1]绵阳市骨科医院骨科,四川绵阳621000 [2]绵阳市中心医院骨科,四川绵阳621000

出　　处：《临床和实验医学杂志》2023年第3期296-300,共5页Journal of Clinical and Experimental Medicine

基　　金：四川省科技计划项目(编号:2021JDR0337)。

摘　　要：目的探讨外周血血栓素B2(TXB2)、中性粒细胞胞外陷阱(NETs)、6酮前列腺素F1α(6-K-PGF1α)在预测创伤骨折患者深静脉血栓形成中的价值。方法采用前瞻性研究方法,选取2020年1月至2022年1月在绵阳市骨科医院治疗的创伤骨折患者102例。统计分析发生和未发生深静脉血栓患者临床资料,以及手术前后TXB2、NETs、6-K-PGF1α水平差异,并评价TXB2、NETs、6-K-PGF1α在预测创伤骨折术后深静脉血栓形成方面的价值。结果共有16例发生深静脉血栓,发生深静脉血栓患者年龄为(66.70±8.28)岁,明显高于未发生深静脉血栓患者[(56.69±9.43)岁],差异有统计学意义(P<0.05)。术后24 h时,发生深静脉血栓患者TXB2和NETs分别为(154.49±21.05)ng/L和0.68±0.12,明显高于未发生深静脉血栓患者[(140.42±25.01)ng/L、0.56±0.11],而6-K-PGF1α为(11.29±2.82)pg/mL,明显低于未发生深静脉血栓患者[(13.45±1.92)pg/mL],差异有统计学意义(P<0.05)。发生深静脉血栓患者手术前后TXB2、NETs、6-K-PGF1α变化值分别为(23.83±4.33)ng/L、(0.44±0.10)和(5.83±1.10)pg/mL,明显高于未发生深静脉血栓患者[(11.54±3.32)ng/L、0.33±0.12、(3.90±1.02)pg/mL],差异均有统计学意义(P<0.05)。手术前后TXB2、NETs、6-K-PGF1α变化值预测创伤骨折术后深静脉血栓发生的受试者工作特征(ROC)曲线下面积分别为0.972、0.742和0.869。手术前后TXB2、NETs、6-K-PGF1α变化值以并联方式预测静脉血栓的敏感度、阴性预测值均为100.00%,明显高于以串联方式(P<0.05)。结论发生深静脉血栓患者,其术后TXB2和NETs水平明显升高,而6-K-PGF1α水平明显降低。手术前后TXB2、NETs、6-K-PGF1α变化值在预测创伤骨折术后深静脉血栓形成方面有较高的应用价值,值得进一步研究。Objective To investigate the value of thromboxane B2(TXB2),neutrophil extracellular traps(NETs)and 6 Ketoprostaglandin F1α(6-K-PGF1α)in predicting deep vein thrombosis in patients with traumatic fracture.Methods Prospective research methodswereused,selected 102 traumatic fracture patients treated in Mianyang Orthopedic Hospital from January 2020 to January 2022.Statistical analyzed clinical data of occurrence and absence of patients,and TXB2,NETs,6-K-PGF1α(level difference)before and after surgery,and tried to evaluate TXB2,NETs,6-K-PGF1α(value in predicting deep vein thrombosis after traumatic fracture).Results Including 16 patients who had developed DVT.The age of patients with DVT was(66.70±8.28)years,which was significantly higher than that of patients without DVT(P<0.05).The TXB2 and NETs in patients with deep vein thrombosis 24 hours after surgerywere(154.49±21.05)ng/L and(0.68±0.12),respectively,which were significantly higher than those in patients without deep vein thrombosis[(140.42±25.01)ng/L,0.56±0.11],while 6-K-PGF1αwas(11.29±2.82)pg/mL,which was significantly lower than those in patients without deep vein thrombosis[(13.45±1.92)pg/mL],the differences were statistically significant(P<0.05).The changes of TXB2,NETs,6-K-PGF1αin patients with deep vein thrombosis before and after surgery were(23.83±4.33)ng/L,0.44±0.10,and(5.83±1.10)pg/mL,respectively,which were significantly higher than those in patients without deep vein thrombosis[(23.83±4.33)ng/L,(0.44±0.10)and(5.83±1.10)pg/mL],the differences were statistically significant(P<0.05).The area under the receiver operating characteristic(ROC)curve of TXB2,NETs,6-K-PGF1αchanges before and after surgery to predict the occurrence of deep vein thrombosis after traumatic fracture surgery was 0.972,0.742 and 0.869,respectively.The sensitivity and negative predictive value of TXB2,NETs,6-K-PGF1αchanges in parallel mode to predict venous thrombosis before and after surgery were 100.00%,which were significantly higher than those in series mod

关 键 词：血栓素B2 中性粒细胞胞外陷阱 6酮前列腺素F1α 创伤骨折 深静脉血栓 预测价值 

分 类 号：R683[医药卫生—骨科学] R543.6[医药卫生—外科学]