复方甘草酸苷联合西咪替丁治疗过敏性紫癜患儿的效果  

Effects of compound glycyrrhizin combined with Cimetidine in treatment of children with allergic purpura

作　　者：刘瑞雪 LIU Ruixue(Department of Pediatrics of Qi County People’s Hospital,Kaifeng 475200 Henan,China)

机构地区：[1]杞县人民医院儿科,河南开封475200

出　　处：《中国民康医学》2023年第4期89-92,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:观察复方甘草酸苷联合西咪替丁治疗过敏性紫癜患儿的效果。方法:回顾性分析2018年1月至2021年5月该院收治的120例过敏性紫癜患儿的临床资料,按照治疗方法不同将其分为对照组与观察组各60例。两组均进行基础治疗,在此基础上,对照组予以西咪替丁治疗,观察组在对照组基础上联合复方甘草酸苷治疗,两组均连续治疗2周。比较两组临床疗效、治疗前后血清免疫球蛋白[免疫球蛋白A(IgA)、免疫球蛋白E(IgE)]水平、临床症状(皮肤紫癜、关节疼痛、腹痛、肾损伤)消失时间、住院时间、治疗前后炎性指标[白细胞介素-6(IL-6)、白细胞介素-10(IL-10)、肿瘤坏死因子-α(TNF-α)]水平和不良反应发生率。结果:观察组治疗总有效率为96.67%(58/60),高于对照组的83.33%(50/60),差异有统计学意义(P<0.05);治疗后,观察组IgA、IgE、IL-6、IL-10、TNF-α水平均低于对照组,差异有统计学意义(P<0.05);观察组皮肤紫癜、关节疼痛、腹痛、肾损伤等症状消失时间和住院时间均短于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:复方甘草酸苷联合西咪替丁治疗过敏性紫癜患儿可提高治疗总有效率,降低血清免疫球蛋白水平和炎性指标水平,缩短临床症状消失时间和住院时间,效果优于单纯西咪替丁治疗。Objective:To observe effects of compound glycyrrhizin combined with Cimetidine in treatment of children with allergic purpura.Methods:The clinical data of 120 children with allergic purpura admitted to the hospital from January 2018 to May 2021 were retrospectively analyzed.They were divided into control group and observation group according to different treatment methods,60 cases in each.Both groups received basic treatment.On this basis,the control group was treated with Cimetidine,while the observation group was treated with compound glycyrrhizin on the basis of that of the control group.Both groups were treated for 2 weeks.The clinical efficacy,the serum immunoglobulin levels[immunoglobulin A(IgA),immunoglobulin E(IgE)]before and after the treatment,the disappearance time of clinical symptoms(skin purpura,joint pain,abdominal pain,renal injury),the hospitalization time,the inflammatory indicator levels before and after the treatment[interleukin-6(IL-6),interleukin-10(IL-10),tumor necrosis factor-α(TNF-α)],and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of treatment in the observation group was 96.67%(58/60),which was higher than 83.33%(50/60)in the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of IgA,IgE,IL-6,IL-10 and TNF-αin the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).The disappearance time of skin purpura,joint pain,abdominal pain,renal injury and the hospitalization time in the observation group were shorter than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Compound glycyrrhizin combined with Cimetidine in the treatment of the children with allergic purpura can improve the total effective rate of treatment,reduce the serum immunoglobulin levels a

关 键 词：过敏性紫癜 儿童 西咪替丁 复方甘草酸苷 免疫球蛋白 炎性指标 

分 类 号：R554.6[医药卫生—血液循环系统疾病]