鸟嘌呤核苷酸结合蛋白q多肽在哺乳动物繁殖调控中的研究进展  

Research Progress of Guanine Nucleotide Binding Protein q Polypeptide on Regulation of Mammalian Reproduction

作　　者：王唯 贺小云[1] 储明星[1] WANG Wei;HE Xiao-Yun;CHU Ming-Xing(Key Laboratory of Animal Genetics,Breeding and Reproduction of Ministry of Agriculture and Rural Affairs,Institute of Animal Science,Chinese Academy of Agricultural Sciences,Beijing 100193,China)

机构地区：[1]中国农业科学院北京畜牧兽医研究所农业农村部动物遗传育种与繁殖重点实验室,北京100193

出　　处：《农业生物技术学报》2023年第3期643-649,共7页Journal of Agricultural Biotechnology

基　　金：国家自然科学基金项目(32102508,32172704);财政部和农业农村部:国家现代农业产业技术体系资助(CARS-38);中国农业科学院科技创新工程(CAAS-ZDRW202106和ASTIP-IAS13);中国农业科学院北京畜牧兽医研究所基本科研业务费项目(2021-YWF-ZYSQ-14)。

摘　　要：鸟嘌呤核苷酸结合蛋白q多肽(guanine nucleotide binding protein q polypeptide,GNAQ)是q类G蛋白的α亚基成员,在细胞信号传递中发挥着重要作用。有研究表明GNAQ在多个生殖相关组织中参与哺乳动物的繁殖调控。本文主要就GNAQ的发现、作用机制以及在哺乳动物下丘脑激素分泌、子宫功能、卵巢生理、雄性睾丸发育和精子发生等繁殖方面的研究进展进行综述,为后续深入探究GNAQ在哺乳动物繁殖过程中的作用机制提供参考。The guanine nucleotide-binding protein q polypeptide(GNAQ)is a member of theαsubunit encoding of the q-class G protein and is vital in cell signaling.Studies have shown that GNAQ plays an important role in multiple reproductive-related tissues involved in mammalian reproductive regulation.The present review is concerned with the discovery and mechanism of action of GNAQ,the research progress of GNAQ in mammalian hypothalamic hormone secretion,uterine function,ovarian physiology,male testicular development,and spermatogenesis.This review provides a reference for further exploring the mechanism of GNAQ in mammalian reproduction.

关 键 词：哺乳动物 鸟嘌呤核苷酸结合蛋白q多肽(GNAQ) 繁殖调控 性腺 激素分泌 

分 类 号：S826[农业科学—畜牧学]