基于“肠道菌群—宿主免疫”轴探讨风湿免疫病脾虚湿阻病机的生物学基础  

Exploring the Biological Basis of Spleen Deficiency and Dampness of Rheumatic Diseases Based on the Axis of“Gut microbiota-Host’s Immunity”

作　　者：何志兴[1] 黄琳[1] 邵铁娟[1] 温成平[1] Zhixing He;Lin Huang;Tiejuan Shao;Chengping Wen(Institute of Basic Research in Clinical Medicine and College of Basic Medical Science,Zhejiang Chinese Medical University,Hangzhou 310053)

机构地区：[1]浙江中医药大学基础医学院/中医临床基础研究所,杭州310053

出　　处：《中国科学基金》2023年第1期78-84,共7页Bulletin of National Natural Science Foundation of China

摘　　要：风湿免疫病是以人体自身反应性T、B细胞过度活化,大量产生自身抗体,并引发多器官多系统损伤为主要特征的慢性炎症性疾病。脾虚湿阻是风湿免疫病常见中医病机,贯穿于疾病的发生发展。肠道菌群平衡是脾主运化发挥功能的前提,而肠道菌群紊乱是脾虚湿阻的重要病理因素。此外,肠道菌群在风湿免疫病中的研究方兴未艾,肠道菌群通过调控宿主免疫达到影响风湿免疫病的作用。因此,“肠道菌群—宿主免疫”可能是构建脾虚湿阻与风湿免疫病两者关联的桥梁,是研究脾虚湿阻诱发风湿免疫病生物学机制的突破口。本文分别论述了肠道菌群、风湿免疫病和脾虚湿阻三者之间的联系,并就现有研究进行了分析与展望。Rheumatic disease(RD)is a chronic inflammatory disease characterized by excessive activation of T and B cells,causing massive production of autoantibodies and multi-organ damage.Spleen deficiency and dampness is the main syndrome of RD over the occurrence and development of RD.The balance of gut microbiota is the prerequisite for the spleen governing transportation and transformation,and intestinal dysbiosis is an important pathological factor of spleen deficiency and dampness.In addition,the research on the role of gut microbiota in RD is in the ascendant,since gut microbiota can affect the severity of RD by regulating the host’s immunity.Therefore,“gut microbiota-host’s immunity”may be a bridge to build the relationship between spleen deficiency and dampness and RD,and it is also a breakthrough to study the biological mechanism of spleen deficiency and dampness in RD.This study discusses the relationships among gut microbiota,RD,and spleen deficiency and dampness,further analyzes and prospects the existing research.

关 键 词：风湿免疫病 脾虚湿阻 肠道菌群 宿主免疫 中西医 

分 类 号：R259[医药卫生—中西医结合]