Konjac-mulberry leaf compound powder alleviates OVA-induced allergic rhinitis in BALB/c mice  

作　　者：Yiyun Zhang Jinxing Wang Qi Zhang Liling Deng Siyao Miao Geng Zhong 

机构地区：[1]College of Food Science,Southwest University,Chongqing 400715,China [2]WESTA College,Southwest University,Chongqing 400715,China [3]Chongqing Institute of Biotechnology Co.,Ltd.,Chongqing 401121,China [4]National Undergraduate Experimental Teaching Demonstration Center of Food Science and Engineering,Southwest University,Chongqing 400715,China

出　　处：《Food Science and Human Wellness》2023年第5期1674-1682,共9页食品科学与人类健康（英文）

基　　金：financially supported by Chongqing Undergraduate Training Programs for Innovation and Entrepreneurship (S201910635126);approved by the Natural Science Foundation of Chongqing Province-Level Municipality,China (cstc2018jcyjAX0527)。

摘　　要：According to the proportion of 1:1, konjac flour and mulberry leaf powder are compounded into a kind of dietary fiber source(KMCP). It is found to be good for anti-inflammation. However, its precise anti-allergic rhinitis effect and mechanism remain unknown. In our work, the effect of KMCP on allergic rhinitis(AR)induced by ovalbumin(OVA)was investigated. We found that the number of nasal rubbing and sneezing, the eosinophil(EOS)count in the nasal mucosa, and the serum levels of histamine(HIS), OVA-specific immunoglobulin E(OVA-sIgE)and interleukin-4(IL-4)were decreased, and the histopathological changes of nasal mucosa were inhibited. Additionally, the experiments further proved that the KMCP treatment could exert substantial effects on short-chain fatty acids(SCFAs)metabolism in the cecum as well. Overall findings suggest that KMCP could suppress the inflammatory response in AR mice, and serve as a novel curative therapeutic for AR without side effects.

关 键 词：Konjac-mulberry leaf compound powder Allergic rhinitis Inflammatory response Short-chain fatty acids 

分 类 号：R285.5[医药卫生—中药学]