动脉导管未闭新生儿母亲妊娠期高危因素分析  

Maternal High-risk Factors of Neonatal Patent Ductus Arteriosus during Pregnancy

作　　者：姜露 王军 杨倩倩 JIANG Lu;WANG Jun;YANG Qianqian(Department of Neonatology,The Affiliated Hospital of Xuzhou Medical University,Jiangsu 221000,China)

机构地区：[1]徐州医科大学附属医院,221000

出　　处：《医学研究杂志》2023年第2期158-161,共4页Journal of Medical Research

摘　　要：目的分析动脉导管未闭(patent ductus arteriosus,PDA)新生儿母亲妊娠期高危影响因素,为早期预防、早期干预提供参考方向。方法将2018年9月~2022年2月在徐州医科大学附属医院产科出生并且生后24h内转入徐州医科大学附属医院新生儿重症监护室(NICU)的254例新生儿作为研究对象。根据生后1周内的心脏彩超结果分类,分为PDA组(n=151)与非PDA组(n=103),运用SPSS软件,比较两组的临床资料,以此分析动脉导管未闭新生儿母亲妊娠期的高危因素。结果单因素分析显示两组患儿胎龄、出生体重、胎儿宫内窒息史、1min Apgar评分、妊娠期贫血、胎膜早破、炎性指标高、羊水异常、产前使用地塞米松、产前1周使用抗生素及产前1周母亲的体重指数(body mass index,BMI)指数比较,差异有统计学意义(p<0.05),是引起新生儿动脉导管未闭的高危因素;二元Logistic回归分析显示,产前使用地塞米松是新生儿动脉导管未闭的保护性因素,而妊娠期贫血、胎膜早破、炎性指标高,母亲产前BMI高是新生儿动脉导管未闭的危险因素。结论妊娠期贫血、感染、BMI高可能会增加新生儿动脉导管未闭的风险,需要妊娠期注意贫血、体重增长的情况以及避免感染。Objective To analyze the maternal high-risk factors of neonatal patent ductus arteriosus(PDA)during pregnancy,so as to provide reference for early prevention and intervention.Methods A total of 254 neonates who were born in the Department of Obstetrics,the Affiliated Hospital of Xuzhou Medical University from September 2018 to February 2022 and transferred to the neonatal intensive care unit(NICU)within 24h after birth were selected as the subjects.They were divided into PDA group(n=151)and non-PDA group(n=103)according to the cardiac color Doppler ultrasound results within 1 week after birth.SPSS software was used to compare the clinical data of the two groups,so as to analyze the maternal high-risk factors of neonatal PDA durning pregnancy.Results Univariate analysis showed that gestational age,birth weight,history of intrauterine asphyxia,1-minute Apgar score,anemia during pregnancy,premature rupture of membranes,high inflammatory indicators,abnormal amniotic fluid,prenatal use of Dexamethasone,use of antibiotics at 1 week before delivery and high maternal BMI at 1 week before delivery were statistically significant(P<0.05),they were the high-risk factors for neonatal PDA.Multivariate Logistic regression analysis showed that the prenatal use of Dexamethasone was a protective factor for neonatal PDA,while anemia during pregnancy,premature rupture of membranes,high inflammatory indicators,and high maternal prenatal BMI were risk factors for neonatal PDA.Conclusion Anemia,infection and high BMI during pregnancy may increase the risk of neonatal PDI.Attention should be paid to anemia and weight gain during pregnancy and to avoid infection.

关 键 词：新生儿 动脉导管未闭 妊娠期高危因素 

分 类 号：R72[医药卫生—儿科]