益气活血通络方加减治疗气虚血瘀型慢性萎缩性胃炎25例临床观察  

Clinical effect of modified Yiqi Huoxue Tongluo prescription in treatment of chronic atrophic gastritis with Qi deficiency and blood stasis:An analysis of 25 cases

作　　者：佘荣荣 郭金伟[1] 葛惠男[1] SHE Rongrong;GUO Jinwei;GE Huinan(Suzhou Hospital of Traditional Chinese Medicine Affiliated to Nanjing University of Chinese Medicine,Suzhou 215000,Jiangsu,China)

机构地区：[1]南京中医药大学附属苏州市中医医院,江苏苏州215000

出　　处：《湖南中医杂志》2023年第2期8-12,共5页Hunan Journal of Traditional Chinese Medicine

基　　金：国家中医药管理局吴门医派杂病流派传承工作室建设项目(国中医药人教函[2019]62号);江苏省名老中医药传承工作室建设项目(苏中医科教[2019]10号);苏州市科技发展计划项目(SYSD2019243);苏州市中医医院青年项目(YQN2021005)。

摘　　要：目的:观察益气活血通络方加减治疗气虚血瘀型慢性萎缩性胃炎(CAG)的临床疗效。方法:将50例气虚血瘀型CAG患者随机分为治疗组与对照组,每组各25例。治疗组予以益气活血通络方加减治疗,对照组予以胃复春片治疗,均治疗3个月。观察2组患者的综合疗效、中医证候疗效及中医证候积分、胃镜评分、组织病理评分。结果:综合疗效总有效率治疗组为76.00%(19/25),对照组为40.00%(10/25),2组比较,差异有统计学意义(P<0.05)。中医证候疗效总有效率治疗组为100.00%(25/25),对照组为76.00%(19/25),2组比较,差异有统计学意义(P<0.01)。2组中医证候积分、胃镜评分、组织病理评分治疗前后组内比较及治疗后组间比较,差异均有统计学意义(P<0.01或P<0.05)。治疗组治疗后胃黏膜改善程度优于对照组(P<0.05)。结论:益气活血通络方加减治疗气虚血瘀型CAG疗效显著,能有效缓解患者症状,改善其内镜下表现及病理组织学表现。Objective: To investigate the clinical effect of modified Yiqi Huoxue Tongluo prescription in the treatment of chronic atrophic gastritis(CAG) with Qi deficiency and blood stasis.Methods: A total of 50 patients with CAG with Qi deficiency and blood stasis were randomly divided into treatment group and control group, with 25 patients in each group.The patients in the treatment group were given modified Yiqi Huoxue Tongluo prescription, while those in the control group were given Weifuchun tablets, and the course of treatment was 3 months for both groups.The two groups were observed in terms of overall response, treatment outcome of traditional Chinese medicine(TCM) syndrome, TCM syndrome score, gastroscopy score, and histopathological score.Results: There was a significant difference in overall response rate between the treatment group and the control group [76.00%(19/25) vs 40.00%(10/25),P<0.05],and there was also a significant difference between the two groups in the overall response rate of TCM syndrome [100.00%(25/25) vs 76.00%(19/25),P<0.01].After treatment, both groups had significant changes in TCM syndrome score, gastroscopy score, and histopathological score, and there were significant differences in these scores between the two groups after treatment(P<0.01 or P<0.05).Compared with the control group, the treatment group had a significantly better improvement in gastric mucosa after treatment(P<0.05).Conclusion: Modified Yiqi Huoxue Tongluo prescription has a marked clinical effect in the treatment of CAG with Qi deficiency and blood stasis and can effectively alleviate symptoms and improve endoscopic and histopathological manifestations.

关 键 词：慢性萎缩性胃炎 气虚血瘀型 益气活血通络方加减 

分 类 号：R259.733.2[医药卫生—中西医结合]