^(68)Ga-FAPI PET/CT在肥厚型心肌病的初步探索性研究  

^(68)Ga-FAPI PET/CT in hypertrophic cardiomyopathy:A pilot study

作　　者：平措云旦 古宇帆 韩凯[2] 汪蕾[2] 方纬[2] 闫朝武[2] PING Cuoyundan;GU Yufan;HAN Kai;WANG Lei;FANG Wei;YAN Chaowu(Department of Structural Heart Disease,National Center for Cardiovascular Diseases and Fuwai Hospital,CAMS and PUMC,Beijing 100037,China;不详)

机构地区：[1]中国医学科学院北京协和医学院、国家心血管病中心-阜外医院、结构性心脏病中心,100037 [2]中国医学科学院北京协和医学院、国家心血管病中心-阜外医院、核医学科,100037

出　　处：《心肺血管病杂志》2023年第2期158-162,共5页Journal of Cardiovascular and Pulmonary Diseases

摘　　要：目的:初步探讨^(68)Ga标记成纤维细胞激活蛋白抑制剂(^(68)Ga-FAPI)PET/CT在肥厚型心肌病患者的图像特点及临床应用价值。方法:前瞻性纳入5例肥厚型心肌病患者,其中男性3例,平均年龄(61±6)岁。均进行^(68)Ga-FAPI PET/CT显像,分别计算左心室心肌和血池(左心房)的最大标准化摄取值(SUVmax),并采用t检验进行比较。心脏磁共振成像(cMRI)用于测定心肌室壁厚度,并同时进行延迟增强(LGE)成像。采用χ^(2)检验分析各心肌节段^(68)GaFAPI摄取的SUVmax与LGE的关系。结果:5例患者均有显著高于血池的心肌^(68)Ga-FAPI摄取[SUVmax分别为(8.83±2.72)和(1.11±0.12),P=0.003],心肌摄取^(68)Ga-FAPI的范围明显大于LGE区域(P<0.001),仅有^(68)Ga-FAPI摄取的区域常位于LGE边缘。透壁LGE区的^(68)GaFAPI摄取强度低于非透壁LGE区。结论:肥厚型心肌病患者左心室心肌有显著的^(68)Ga-FAPI高摄取,且摄取范围明显超过cMRI-LGE区域,初步提示^(68)Ga-FAPI PET/CT对早期鉴别纤维重构可能具有临床应用潜力。Objective:The aim of this study is to preliminarily characterize cardiac uptake and explore the clinical value of^(68)Ga-labeled fibroblast activator inhibitor(^(68)Ga-FAPI)PET/CT imaging in patients with hypertrophic cardiomyopathy(HCM).Methods:Five patients,3 males,average age is(61±6)years,diagnosed with HCM were prospectively enrolled to perform^(68)Ga-FAPI PET/CT imaging.The maximum standardized uptake value(SUVmax)was obtained for left ventricular myocardium and blood pool(left atrium)and the difference between myocardium and blood pool was calculated by Student’s t test.All patients underwent cardiac magnetic resonance imaging(cMRI)to determine the wall thickness and the presence of LGE.By using a 17-segment model,cardiac uptake of^(68)Ga-FAPI was compared with presence of LGE on a segmental basis by Chi-square Test.Results:All patients exhibited significantly increased uptake of^(68)Ga-FAPI in left ventricle relative to blood pool[SUVmax:(8.83±2.72 vs.(1.11±0.12),P=0.003]and all presented with LGE.The distribution of^(68)Ga-FAPI uptake exceeded LGE presence among segments(n=85)(P<0.001).Segments with^(68)Ga-FAPI uptake but absence of LGE localized in peri-LGE regions.Moreover,the intensity of^(68)Ga-FAPI in transmural LGE segments seemed to be lower than that with focal or patchy LGE.Conclusions:^(68)Ga-FAPI PET/CT directly shows fibroblast activation in HCM and^(68)Ga-FAPI uptake area beyond the LGE region,suggesting the potential for detection of fibrotic remodeling.

关 键 词：肥厚型心肌病 正电子发射断层显像术 磁共振成像 成纤维细胞 ^(68)Ga-标记成纤维细胞激活蛋白抑制剂 

分 类 号：R54[医药卫生—心血管疾病]