皮肤偶发分枝杆菌感染二例并文献分析  

Two cases of cutaneous Mycobacterium Fortuitum infection and literature review

作　　者：米州洋 张雍 暴芳芳[1] 刘永霞[1] 陈声利[1] 孙勇虎[1] 张福仁[1] MI Zhouyang;ZHANG Yong;BAO Fangfang;LIU Yongxia;CHEN Shengli;SUN Yonghu;ZHANG Furen(Shandong Provincial Hospital for Skin Diseases&Shandong Provincial Institute of Dermatology and Venereology,Shandong First Medical University,Jinan 250022,China)

机构地区：[1]山东第一医科大学附属皮肤病医院(山东省皮肤病医院),山东省皮肤病性病防治研究所,山东济南250022

出　　处：《中国麻风皮肤病杂志》2023年第4期248-252,共5页China Journal of Leprosy and Skin Diseases

基　　金：山东省泰山学者青年专家计划(编号:tsqn201909141);山东第一医科大学学术提升计划(编号:2020RC001);山东省皮肤性病学临床医学研究中心。

摘　　要：偶发分枝杆菌是一种广泛存在于自然环境的条件致病菌,具有一定的耐药性,常规抗生素治疗效果不佳。现报道皮肤偶发分枝杆菌感染2例,均经过病理及qPCR确诊,应用利福平、克拉霉素治疗4个月后皮损明显消退。本文还对既往报道的466例偶发分枝杆菌感染病例的临床特征进行分析,总结归纳偶发分枝杆菌感染的诊断和治疗特点。Mycobacterium Fortuitum is an opportunistic pathogen widely existing in the natural environment.It has certain drug resistance,and conventional antibiotic treatment is not effective.Here,we reported 2 cases diagnosed as cutaneous Mycobacterium Fortuitum infection through routine pathology and qPCR.After treatment with rifampicin and clarithromycin for 4 months,the skin lesions subsided significantly.The literature were researched,and the characteristics of diagnosis and treatment of 466 cases was analyzed.

关 键 词：偶发分枝杆菌 利福平 克拉霉素 

分 类 号：R751[医药卫生—皮肤病学与性病学]