糖皮质激素联合TNF-α抑制剂成功治疗疱疹样脓疱病二例  

Two cases of impetigo herpetiformis successfully treated by steroid combined with TNF-αinhibitors

作　　者：黎龙珊 李汀影 张小超 刘冬先[1] LI Longshan;LI Tingying;ZHANG Xiaochao;LIU Dongxian(Department of Dermatology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China)

机构地区：[1]华中科技大学同济医学院附属同济医院皮肤病与性病科,武汉430030

出　　处：《中国麻风皮肤病杂志》2023年第4期265-268,共4页China Journal of Leprosy and Skin Diseases

基　　金：国家自然青年科学基金项目(编号:82103606)。

摘　　要：妊娠期疱疹样脓疱病的治疗仍是一个比较棘手的问题,治疗的主要难点在于妊娠用药的局限性。口服激素、环孢素是推荐治疗IH的一线用药方案,在其他药物使用疗效不佳时可谨慎使用生物制剂。既往有使用TNF-α成功治疗IH的病例报道,本文报道的2例疱疹样脓疱病在常规治疗病情控制不佳时,使用了不同的TNF-α拮抗剂,患者的皮损均在分娩之前得到了控制,并分娩出健康新生儿,为IH的治疗提供参考,但更加安全、系统的治疗方案仍需要更多的病例去总结。The treatment of impetigo herpetiformis(IH)during pregnancy remains a challenge and the main difficulty in treatment lies in the limitations of the medications used in pregnancy.Glucocorticoids and cyclosporine are the recommended first-line regimens for the treatment of IH.Biologics may be used cautiously when other drugs are ineffective.It has been reported that IH was successfully treated with TNF-αin the previous literature reports.In this paper,two cases of IH were treated with TNF-αantagonists when conventional treatment failed.Both patients’skin lesions were controlled before delivery,and healthy neonates were delivered,which provided a reference for the treatment of IH.However,more cases are needed for a safer and more systematic treatment plan.

关 键 词：疱疹样脓疱病 IL-36RN TNF-Α抑制剂 

分 类 号：R758.6[医药卫生—皮肤病学与性病学]