超声引导下靶点注射甲钴胺治疗周围神经损伤的疗效分析  

Efficacy Evaluation of Ultrasound-Guided Target Injection of Mecobalamine on Peripheral Nerve Injury

作　　者：刘小曼 梅盛瑞 杨晓娇 钱磊 赵金荣 朱云[1] 杨颖[1] Liu Xiaoman;Mei Shengrui;Yang Xiaojiao;Qian Lei;Zhao Jinrong;Zhu Yun;Yang Ying(Department of Rehabilitation medicine,the People’s Hospital of Suzhou New District,Suzhou 215000,China;Wuxi People’s Hospital,Wuxi 214000,China;Wuxi Ninth People’s Hospital,Wuxi 214000,China)

机构地区：[1]苏州高新区人民医院康复医学科,江苏苏州215000 [2]无锡市人民院,江苏无锡214000 [3]无锡市第九人民医院,江苏无锡214000

出　　处：《实用骨科杂志》2023年第3期214-218,共5页Journal of Practical Orthopaedics

基　　金：2019年苏州高新区医疗卫生科技计划项目(2019F003)。

摘　　要：目的探讨超声引导下靶点注射甲钴胺对周围神经损伤后神经电生理、超声下神经结构、感觉功能的影响。方法本试验将周围神经损伤后功能障碍患者按照1︰1随机纳入试验组及对照组,其中试验组13例,男性9例,女性4例;平均年龄为(33.92±7.54)岁。对照组12例,男9例,女3例;平均年龄为(33.08±11.31)岁。试验组采用超声引导下靶点注射甲钴胺注射液结合常规治疗,对照组采用常规治疗,于治疗前和治疗12周分别进行神经电生理(神经潜伏期、波幅、传导速度)、超声下神经直径及横截面积、英国医学研究委员会(British medical research council,BMRC)感觉功能评定。结果与治疗前对比,两组患者的神经电生理(神经潜伏期、波幅、传导速度)、超声下神经直径及横截面积、神经BMRC感觉评定在治疗后差异有统计学意义(P<0.05);与对照组对比,试验组的超声下神经直径及横截面积、神经BMRC感觉在治疗前后的改变差异有统计学意义(P<0.05)。结论超声引导下靶点注射甲钴胺结合常规治疗对周围神经结构、感觉功能的改善优于常规治疗。Objective To investigate the effect of ultrasound-guided target injection of mecobalamin on nerve electrophysiology,nerve structure under ultrasound and sensory function after peripheral nerve injury.Methods In this study,patients with dysfunction after peripheral nerve injury were randomly divided into the experimental group and the control group at a ratio of 1︰1.There were 13 cases(9 males and 4 females)in the experimental group,with an average age of(33.92±7.54),and 12 cases(9 males and 3 females)in the control group,with an average age of(33.08±11.31).The experimental group received ultrasound-guided target injection of mecobalamin injection combined with conventional therapy,while the control group received conventional therapy.Results were assessed with the nerve electrophysiology(neural latency,amplitude,conduction velocity),nerve diameter and cross-sectional area under ultrasound,and the british medical research council(BMRC)sensory function assessment before treatment and after 12 weeks of treatment.Results Compared with before treatment,the two after treatment groups had statistically significant difference in nerve electrophysiology,nerve diameter and cross-sectional area under ultrasound,and nerve BMRC sensory assessment(P<0.05).Compared with the control group,the difference was statistically significant in the changes of nerve diameter and cross-sectional area and nerve BMRC sensation before and after treatmentin the experimental group(P<0.05).Conclusion Ultrasound-guided targeted injection of mecobalamin combined with conventional therapy is better in improving peripheral nerve structure and sensory function than conventional therapy.

关 键 词：超声引导 靶点注射 周围神经损伤 功能障碍 

分 类 号：R651.3[医药卫生—外科学]