嵌入式相位传感的多功能Stokes-Mueller偏振仪  

Multifunctional Stokes-Mueller Polarimeter Based on Embedded Phase Sensing

作　　者：钟慧 李艳秋 刘克 王嘉智 李员赫 吴劲贤 Zhong Hui;Li Yanqiu;Liu Ke;Wang Jiazhi;Li Yuanhe;Wu Jinxian(Key Laboratory of Photoelectronic Imaging Technology and System,Ministry of Education,School of Optics and Photonics,Beijing Institute of Technology,Beijing 100081,China)

机构地区：[1]北京理工大学光电学院光电成像技术与系统教育部重点实验室,北京100081

出　　处：《光学学报》2023年第2期90-97,共8页Acta Optica Sinica

基　　金：国家自然科学基金(11627808)。

摘　　要：Mueller矩阵因可以定量地提供组织样品的完整偏振信息,已被广泛地应用于癌症的病理诊断中。现有的Mueller成像偏振检测仪器丢失了样品的绝对相位信息,而相对的相位信息不能反映待测相位的变化规律,故需要开发嵌入式偏振光波前绝对相位检测仪器。搭建了一款嵌入式相位传感的Stokes-Mueller偏振仪,将研发的四波横向剪切干涉仪集成在偏振仪中,不仅实现了生物样品偏振信息的提取,还实现了样品相位信息和折射率的实时测量。以肺癌组织切片为研究对象,通过对退偏参数和折射率值的比较准确地实现了对正常区域和癌变区域的识别。所提技术丰富了偏振仪的测量功能,通过测量绝对相位实现了样品折射率的测量,进而能够为癌症诊断领域提供一种更全面的辅助手段。Objective Since polarization imaging technology can extract richer structural and optical information of samples and is highly sensitive to changes in subwavelength microstructures,it has a bright application prospect in biomedicine.The Mueller matrix has been widely used in the pathological diagnosis of cancers because it can quantitatively provide complete polarization information of biomedical specimens.However,the existing Mueller imaging polarimeter loses the absolute phase information of the sample,and the relative phase information cannot reflect the change law of the phase to be measured.Absolute phase,as a basic property of light,quantifies the phase characteristics determined by the physical thickness and refractive index coefficient of the sample and reflects the changes to be measured.As one of the most important optical properties of biological samples,the refractive index has been proven to be useful for describing the optical properties of biological tissues and evaluating pathological tissues.As an absolute-phase detection method,the quadriwave lateral shearing interferometer is highly suitable for phase microscopic imaging and the measurement of absolute phase information of samples due to its advantages,such as no need for additional wavefront reference beam,no special requirements on the light source,and simple structure.However,the applications of the quadriwave lateral shearing interferometer in the pathological diagnosis of cancer tissues are rarely reported.Therefore,an embedded absolute-phase detection instrument needs to be developed to meet the detection requirements of different types of samples.Methods As the existing Mueller imaging polarimeter loses the absolute phase information of the sample,a multifunctional Stokes-Mueller polarimeter based on embedded phase sensing is built.Specifically,the analysis of the polar decomposition equation for the Mueller matrix shows that the Mueller matrix does not retain the absolute phase information of the polarized light,but only contains the ph

关 键 词：测量 偏振 MUELLER矩阵 相位测量 折射率 定量 

分 类 号：O436.3[机械工程—光学工程]