基于脉冲串飞秒激光的血凝块消蚀效果研究  

Blood Clot Ablation Effects Based on Burst-Mode Femtosecond Laser

作　　者：刘骁征 李有楠 张海涛[3] 顾瑛[1,4] 吴巍巍 张童[2] Liu Xiaozheng;Li Younan;Zhang Haitao;Gu Ying;Wu Weiwei;Zhang Tong(School of Optics and Photonics,Beijing Institute of Technology,Beijing 100081,China;Department of Vascular Surgery,Affiliated Beijing Tsinghua Changgung Hospital,School of Clinical Medicine,Tsinghua University,Beijing 102218,China;Key Laboratory of Photonic Control Technology,Ministry of Education,Center for Photonics and Electronics,Department of Precision Instrument,Tsinghua University,Beijing 100084,China;Department of Laser Medicine,First Medical Center of PLA General Hospital,Beijing 100853,China)

机构地区：[1]北京理工大学光电学院,北京100081 [2]清华大学附属北京清华长庚医院血管外科,清华大学临床医学院,北京102218 [3]清华大学精密仪器系激光与光子技术研究室,光子测控技术教育部重点实验室,北京100084 [4]中国人民解放军总医院第一医学中心激光医学科,北京100853

出　　处：《光学学报》2023年第2期167-174,共8页Acta Optica Sinica

摘　　要：脉冲串飞秒激光在工业精密加工中展现出低热高效的特性,有望为血栓清除技术提供新型解决方案。以动物血凝块为消蚀样本,将脉冲串飞秒激光与高速振镜相结合来搭建实验平台,对样本表面进行单层扫描消蚀,使用三维超景深显微镜对消蚀坑进行观察和记录,并与相同平均功率下的传统脉冲模式飞秒激光的消蚀结果进行比较。结果表明,相比于传统脉冲模式,脉冲串飞秒激光可以提升消蚀效率并降低消蚀阈值,具有良好的临床研发潜力。Objective Thromboembolism and thrombosis are the important causes of arterial occlusive diseases.Rapid thrombus removal is one of the key strategies in the treatment of arterial thrombotic diseases.Currently,the most thrombus removal is achieved through surgery.However,conventional thrombus removal procedures,such as open surgery and minimally invasive surgery,have low thrombus removal rate and the risk of vessel wall damage and rupture.As a new laser technology,the burst-mode femtosecond laser has the potential to solve these problems.It shows low thermal effect and high ablation efficiency in industrial precision machining,which is expected to provide a new solution for thrombus removal technology.However,there is a lack of experimental data to verify the actual ablation effects on thrombus with the burstmode femtosecond laser.The ablation effect with the burst-mode femtosecond laser based on animal blood clot samples is studied in this paper.The experimental results show that the burst-mode femtosecond laser improves the ablation efficiency and reduces the ablation threshold,which has great clinical research and development potential.Methods In this study,the ablation experimental platform is established with femtosecond laser and high-speed galvanometer.The laser can output both traditional mode pulses and burst-mode pulses,and the repetition rate is adjustable.In addition,a pair of aperture stops and a pair of reflectors are set in the platform to adjust beam diameter and fold optical path,respectively.The fresh edible duck blood clots purchased in the market are used as ablation samples.During the ablation experiments,the glass tube containing the blood clot samples is inserted into the sample bracket fixed on the z-axis lifting platform.To facilitate detection and observation,a single-layer large-area scanning method is proposed to carry out the ablation experiments.According to repetition rate,pulse energy,scanning speed,and pulse output mode,12 experimental groups are set up.The three-dimensional super d

关 键 词：医用光学 飞秒激光 组织消蚀 脉冲串模式 三维显微成像 

分 类 号：R454.2[医药卫生—治疗学] TN249[医药卫生—临床医学]