S100融合型蛋白及相关皮肤疾病  

S100 Fused-Type Proteins and the Related Dermatosis

作　　者：宋昊 王淳正 吴悠 郭颖[1,2] SONG Hao;WANG Chunzheng;WU You;GUO Ying(Department of Pharmacology,Institute of Materia Medica,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing100050,China;Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study,Institute of Materia Medica,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing100050,China)

机构地区：[1]中国医学科学院北京协和医学院药物研究所药理室,北京100050 [2]中国医学科学院北京协和医学院药物研究所新药作用机制研究与药效评价北京市重点实验室,北京100050

出　　处：《中国皮肤性病学杂志》2023年第1期117-122,共6页The Chinese Journal of Dermatovenereology

基　　金：中国医学科学院医学与健康科技创新工程项目(2021-I2M-1-028);新药作用机制研究与药效评价北京市重点实验室(BZ0150)。

摘　　要：S100融合型蛋白(S100 fused-type proteins,SFTPs)是一组含有钙结合域和重复序列的蛋白质,包括毛透明蛋白、毛透明蛋白样蛋白1、丝聚蛋白、丝聚蛋白2、Hornerin、Repetin和Cornulin共7种蛋白。SFTPs参与表皮分化并维持皮肤屏障功能,其降解产物具有抗菌活性或成为天然保湿因子维持皮肤微环境稳态。SFTPs蛋白表达异常会导致皮肤功能受损,易引发皮肤病;SFTPs基因突变是寻常性鱼鳞病和特应性皮炎的重要遗传易感因素,并与银屑病、斑秃、鳞状细胞癌发病相关。本综述主要对SFTPs的结构特点、生理功能和相关皮肤病进行总结。S100 Fused Type Proteins(SFTPs) are a group of proteins, including Trichohyalin, Trichohyalin-like 1, Filaggrin, Filaggrin2, Hornerin, Repetin and Cornulin.All members of SFTPs contain calcium-binding domains and repeated sequences.SFTPs play critical roles in epidermal differentiation and the skin barrier maintenance.The metabolites of SFTPs also show antibacterial activities or turn into natural moisturizing factors which are important for the skin microenvironment maintenance.The abnormality of SFTPs leads to skin function disorder, and even cause dermatosis. SFTPs gene mutations are vital genetic predisposition factors for ichthyosis vulgaris and atopic dermatitis occurrences, and are related to the pathogenesis of psoriasis, alopecia areata and squamous cell carcinoma as well.In this review, the SFTPs are summarized with their structural properties, physiological functions and related dermatosis.

关 键 词：S100融合型蛋白 寻常性鱼鳞病 特应性皮炎 银屑病 斑秃 

分 类 号：R751[医药卫生—皮肤病学与性病学]