毛囊性鳞状细胞癌1例国内首报  

Follicular Squamous Cell Carcinoma:the First Case in China

作　　者：叶茜 李凤增[1] 陈爱军[1] 方圣[1] YE Qian;LI Fengzeng;CHEN Aijun;FANG Sheng(Department of Dermatology,the First Affiliated Hospital of Chongqing Medical University,Chongqing 400016,China)

机构地区：[1]重庆医科大学附属第一医院皮肤科,重庆400016

出　　处：《中国皮肤性病学杂志》2023年第2期213-216,共4页The Chinese Journal of Dermatovenereology

摘　　要：患者女,81岁,右面部皮疹逐渐增大、破溃伴痒1年。患者右面部可见约2.0 cm×1.5 cm大小的暗红色结节斑块,形状及边缘不规则,中央破溃结痂,触之质地坚实,有浸润感,无压痛。皮损组织病理示:毛囊漏斗部扩张,可见由毛囊壁产生鳞状细胞团块,呈条索状从毛囊壁向四周呈放射状浸润生长,可见明显的肿瘤细胞异型及核分裂象。免疫组织化学:CK、EMA、p63、p53、p16强阳性;CEA、Ber-EP4阴性;Ki-67约20%(+)。结合临床表现、组织病理及免疫组织化学检查,诊断为毛囊性鳞状细胞癌,予以手术扩大切除,预后良好。An 81-year-old female patient presented to our department with skin lesions on her right face that have gradually increased with central ulceration for one year. There was a dark red infiltrative nodular plaque about 2.0 cm×1.5 cm in size on the right side of the face, irregular in shape and border, with crusting in the middle of the lesion, firm in texture and without tenderness. Histopathological findings revealed the tumor nest arising from the hair follicle, which originated from the follicular, with dilation of the follicular infundibulum and marked cellular atypia and mitosis. Immunohisto-chemistry showed CK, EMA, p63, p53 and p16 strongly positive;CEA and Ber-EP4 was negative;Ki-67>20%(+). The diagnosis of follicular squamous cell carcinoma was confirmed based on clinical lesion, pathology and immunohistochemistry. The patient underwent wide surgical excision, and the prognosis was favorable.

关 键 词：鳞状细胞癌 毛囊性 首报 

分 类 号：R1751[医药卫生—妇幼卫生保健] R739.5[医药卫生—公共卫生与预防医学]