含连续全碳季碳手性中心天然产物的全合成研究进展  

Recent advances in total synthesis of natrual products containing contiguous all carbon quaternary stereocenters

作　　者：张仲超 杨震 Zhongchao Zhang;Zhen Yang(Laboratory of Chemical Genomics,School of Chemical Biology and Biotechnology,Peking University Shenzhen Graduate School,Shenzhen 518055,China;Beijing National Laboratory for Molecular Science and Key Laboratory of Bioorganic Chemistry and Molecular Engineering of the Ministry of Education,College of Chemistry and Molecular Engineering and Peking-Tsinghua Center for Life Sciences,Peking University,Beijing 100871,China;Shenzhen Bay Laboratory,Shenzhen 518055,China)

机构地区：[1]北京大学深圳研究生院,化学生物学与生物技术学院,省部共建肿瘤化学基因组学国家重点实验室,深圳518055 [2]北京大学化学与分子工程学院,北大-清华生命科学联合中心,生物有机与分子工程教育部重点实验室,北京分子科学国家实验室,北京100871 [3]深圳湾实验室,深圳518055

出　　处：《中国科学：化学》2023年第3期277-288,共12页SCIENTIA SINICA Chimica

基　　金：国家自然科学基金(编号:21472006,21572009,21772004,21632002)资助项目。

摘　　要：连续全碳季碳手性中心是活性天然产物中常见且具有合成挑战性的结构单元.本文首先介绍了本研究组在含连续全碳季碳手性中心天然产物的全合成研究进展;随后对含多个(≥3)连续全碳季碳手性中心天然产物的合成策略进行分类;最后以Waihoensene和Crinipellins家族天然产物的全合成研究为例,结合其他课题组报道的全合成研究,对比分析相关合成方法学及合成策略的优势和不足.Contiguous all carbon quaternary stereocenters are common structural units in bioactive natural products with significant synthetic challenges.In this paper,we reviewed our recent progresses in total synthesis of complex natural products containing contiguous all carbon quaternary stereocenters firstly.Then,four different synthetic strategies concerning the construction of contiguous all carbon quaternary stereocenters(≥3)were summarized.Finally,the total synthesis of waihoensene and crinipellins reported by us and other groups were taken as examples to clarify the advantages and disadvantages of various synthetic methodologies and synthetic strategies.

关 键 词：天然产物 连续全碳季碳手性中心 合成方法学 合成策略 

分 类 号：O629[理学—有机化学]