表观遗传调控在畜禽脂肪沉积机制中的研究进展  

Research Progress of Epigenetic Regulation in Fat Deposition Mechanism of Livestock and Poultry

作　　者：金美林 李桃桃 孙东晓[2] 魏彩虹[1] JIN Meilin;LI Taotao;SUN Dongxiao;WEI Caihong(Institute of Animal Sciences,Chinese Academy of Agricultural Sciences,Beijing 100193,China;College of Animal Science and Technology,China Agricultural University,Beijing 100193,China)

机构地区：[1]中国农业科学院北京畜牧兽医研究所,北京100193 [2]中国农业大学动物科技学院,北京100193

出　　处：《畜牧兽医学报》2023年第3期855-867,共13页ACTA VETERINARIA ET ZOOTECHNICA SINICA

基　　金：国家肉羊产业技术体系项目(CARS-38);国家自然科学基金(32272851)。

摘　　要：表观遗传学是DNA序列没有发生改变,基因表达和表型产生可遗传的变化。前期研究发现,表观遗传调控参与多种生命活动过程,在脂肪沉积过程中也发挥重要的作用。脂肪沉积影响畜禽肉品质,研究脂肪沉积机制是畜禽育种中的一个重要方面。因此,本文从DNA甲基化、mRNA修饰、组蛋白修饰、染色体重塑和非编码RNA调控五个方面展开对畜禽脂肪沉积机制中研究进展的综述。Epigenetic modifications are heritable changes in gene expression and phenotype without changing in the DNA sequence. Previous studies have shown that epigenetic regulation is involved in many life processes and plays an important role in fat deposition. Moreover, fat deposition is an important factor affecting the meat quality of livestock and poultry. Studying the mechanism of fat deposition is a significant aspect of breeding. In this review, the research progress of DNA methylation, mRNA modification, histone modification, chromosomal remodeling, and non-coding RNA regulation on the mechanism of fat deposition in livestock and poultry were summerized.

关 键 词：表观遗传学 脂肪沉积 DNA甲基化 mRNA修饰 组蛋白修饰 非编码RNA 

分 类 号：S852.23[农业科学—基础兽医学]