miRNA介导应激幼畜肠道损伤的研究进展  

Research Progress of Intestinal Injury in Young Farm Animals under Stress Mediated by miRNA

作　　者：韩露露 韩德平[2] 赵启南 刁其玉[1] 崔凯[1] HAN Lulu;HAN Deping;ZHAO Qinan;DIAO Qiyu;CUI Kai(Key Laboratory of Feed Biotechnology,Ministry of Agriculture and Rural Affairs,Institute of Feed Research of Chinese Academy of Agricultural Sciences,Beijing 100081,China;College of Veterinary Medicine,China Agricultural University,Beijing 100193,China;Inner Mongolia Academy of Agricultural&Animal Husbandry Sciences,Hohhot 010031,China)

机构地区：[1]中国农业科学院饲料研究所农业农村部饲料生物技术重点实验室,北京100081 [2]中国农业大学动物医学院,北京100193 [3]内蒙古自治区农牧业科学研究院,呼和浩特010031

出　　处：《畜牧兽医学报》2023年第3期877-888,共12页ACTA VETERINARIA ET ZOOTECHNICA SINICA

基　　金：国家自然科学基金面上项目(32172764);“科技兴蒙”合作引导项目(2021CG0024)。

摘　　要：随着畜牧业的飞速发展,集约化饲养、幼畜早期断奶策略应运而生,同时各种应激(如:热应激、冷应激、断奶应激、运输应激、氧化应激)增加,导致免疫系统还未完全建立的幼畜肠道损伤,严重时危及生命。miRNA是一类可调控基因表达的内源性非编码单链小分子RNA,是基因家族的重要成员,参与机体内部几乎所有的信号通路,能够调控肠上皮细胞的增殖与分化,介导肠黏膜屏障损伤。本文综述了应激对肠黏膜屏障功能的影响,miRNA对幼畜肠黏膜屏障功能的调控作用及可能作用途径。同时,综述了miRNA参与外源添加剂作用的模式,为营养素靶向干预调控幼畜肠道免疫功能提供理论依据,对提高幼畜培育具有重要意义。With the rapid development of animal husbandry, intensive feeding and early weaning strategy comes into being. At the same time, all kinds of stress(such as heat stress, cold stress, weaning stress, transport stress, oxidative stress) increase, resulting in intestine injury of young farm animals whose immune system has not been fully established, which is life-threatening in serious cases. miRNA is a kind of endogenous non-coding single-stranded small RNA, which can regulate gene expression. As an important member of the gene family, miRNA was involved in almost all the signaling pathways in the body. miRNA could regulate the proliferation and differentiation of intestinal epithelial cells and mediate intestinal mucosal barrier injury. This review summarized the effect of stress on intestinal mucosal barrier function, the regulatory role and possible pathways of miRNA on intestinal mucosal barrier function of young farm animals. At the same time, the mode of miRNA participating in the action of exogenous additives was reviewed to provide a theoretical basis for nutrients targeted intervention to regulate the intestinal immune function of young farm animals, and was of great significance to improve the breeding of young farm animals.

关 键 词：应激 MIRNA 肠黏膜屏障 

分 类 号：S813[农业科学—畜牧学] S815.7[农业科学—畜牧兽医]