转化生长因子-β/Smads信号通路在急性心肌梗死左心室重构中的研究进展  

Research progress of transforming growth factor-β/Smads signaling pathway in left ventricular remodeling in acute myocardial infarction

作　　者：张成森[1] 刘锐 鲍永辉 时金栗 李长江[1] ZHANG Cheng-sen;LIU Rui;BAO Yong-hui;SHI Jin-li;LI Chang-jiang(Department of Emergency,Affiliated Qingdao Central Hospital of Qingdao University,Qingdao 266042,China)

机构地区：[1]青岛大学附属青岛市中心医院急救中心,山东省青岛市266042

出　　处：《中国心血管病研究》2023年第3期213-218,共6页Chinese Journal of Cardiovascular Research

摘　　要：急性心肌梗死后产生的左心室病理性重构可使心脏部分功能发生进行性减退,这也是导致心力衰竭产生及发展的关键因素。急性心肌梗死左心室重构常表现为心肌细胞发生代偿性增生、心肌间质成纤维细胞形成以及细胞外基质代谢功能遭到破坏等,尤其以Ⅰ型胶原和Ⅲ型胶原的增多和胶原比例的改变最为显著。转化生长因子-β(transforming growth factor-β1,TGF-β)/Smads信号转导通路可参与多种器官组织的调节,也是重要的促心室重构生长因子,其异常表达与临床上多种心血管疾病的发生发展具有重要相关。TGF-β可通过调节Smads通路参与心脏成纤维细胞增殖,并对调控Ⅰ、Ⅲ型胶原蛋白的表达及改善心室重构均具重要干预作用。TGF-β且作为一类可对多数细胞产生刺激的多功能细胞因子主要由Smads所介导,并可在参与维持细胞正常生理功能中发挥关键作用,而在心力衰竭中抑制心肌纤维化形成是预防和治疗心肌梗死后心室重构的关键所在。因此,通过TGE-β/Smads信号转导通路确定相关治疗靶点和分子机制对抑制心脏成纤维细胞增殖及探究急性心肌梗死左心室重构具有十分重要的意义。Pathological remodeling of left ventricle after acute myocardial infarction can lead to progressive decline of partial cardiac function,which is also a key factor leading to the generation and development of heart failure.Left ventricular remodeling in acute myocardial infarction is often manifested by compensatory proliferation of myocardial cells,formation of myocardial interstitial fibroblasts and destruction of extracellular matrix metabolism,especially the increase of typeⅠcollagen and typeⅢcollagen and the change of collagen proportion.Transforming growth factor-β1(TGF-β)/Smads signal transduction pathway can be involved in the regulation of various organs and tissues,and is also an important pro-ventricular remodeling growthfactor,and its abnormal expression is associated with the occurrence and development of a variety of cardiovascular diseases.TGF-βcan participate in the proliferation of cardiac fibroblasts by regulating the Smads pathway,and play an important intervention role in regulating the expression of typeⅠand typeⅢcollagen and improving ventricular remodeling.TGF-β,as a kind of multifunctional cytokines that can stimulate most cells,is mainly mediated by Smads,and can play a key role in maintaining the normal physiological function of cells,while inhibiting the formation of myocardial fibrosis in heart failure is the key to preventing and treating ventricular remodeling after myocardial infarction.Therefore,it is of great significance to identify therapeutic targets and molecularmechanismsthroughTGE-β/Smads signal transduction pathways to inhibit cardiac fibroblast proliferation and explore left ventricular remodeling in acute myocardial infarction.

关 键 词：转化生长因子-β/Smads 急性心肌梗死 左心室重构 

分 类 号：R541.4[医药卫生—心血管疾病]