胶原蛋白的开发与应用研究进展  

Research, development and application of collagen: a review

作　　者：叶滔 项琪[1,2,3] 杨艳[1,2,4] 黄亚东 YE Tao;XIANG Qi;YANG Yan;HUANG Yadong(College of Life Science and Technology,Jinan University,Guangzhou 510632,Guangdong,China;Guangdong Provincial Key Laboratory of Bioengineering Medicine,Institute of Biomedicine,Jinan University,Guangzhou 510632,Guangdong,China;Biopharmaceutical Research and Development Center of Jinan University,Guangzhou 510632,Guangdong,China;Jinan University&TYRAN Cosmetics Innovation Research Institute,Guangzhou 511447,Guangdong,China)

机构地区：[1]暨南大学生命科学技术学院,广东广州510632 [2]暨南大学生物医药研究院,广东省生物工程药物重点实验室,广东广州510632 [3]广州暨南大学医药生物技术研究开发中心有限公司,广东广州510632 [4]暨南大学-肽源化妆品创新研究院,广东广州511447

出　　处：《生物工程学报》2023年第3期942-960,共19页Chinese Journal of Biotechnology

基　　金：广东省重点领域研发计划(2022B1111080007);广东省基础与应用基础研究基金自然科学基金项目(2021A1515012480);广州市重点领域研发计划专项(202103030003);广东省高校创新专项(2019KTSCX011)。

摘　　要：胶原蛋白(collagen)是一类哺乳动物细胞外基质中的主要结构蛋白,广泛地存在于皮肤、骨骼、肌肉等组织中,主要参与细胞的增殖、分化、迁移和信号传递等生理生化行为,对组织细胞等起着支撑、修复、保护的作用。由于胶原蛋白具有良好的生物学特性,其在组织工程、临床医学、食品工业、包装材料、化妆品、医学美容、生物材料以及医疗器械等方面都有着广泛的应用。本文综述了胶原蛋白的生物学特性及其在国内外生物工程研究开发中的研究进展,并对胶原蛋白未来开发的前景进行了展望。Collagen, which widely exists in skin, bone, muscle and other tissues, is a major structural protein in mammalian extracellular matrix. It participates in cell proliferation, differentiation, migration and signal transmission, plays an important role in tissue support and repair and exerts a protective effect. Collagen is widely used in tissue engineering, clinical medicine, food industry, packaging materials, cosmetics and medical beauty due to its good biological characteristics. This paper reviews the biological characteristics of collagen and its application in bioengineering research and development in recent years. Finally, we prospect the future application of collagen as a biomimetic material.

关 键 词：胶原蛋白 生物工程 开发与应用 研究进展 

分 类 号：TQ936.2[化学工程]