2-芳基苯(吡啶)并呋喃类化合物的合成及抗真菌活性  

Synthesis and antifungal activity of 2-aryl benzofuran or furopyridine derivatives

作　　者：李定邦 李鑫[1] 丁彦丽 沙静 李萍[1] 王欢欢 潘乐 金鹿 周蓉 LI Ding-bang;LI Xin;DING Yan-li;SHA Jing;LI Ping;WANG Huan-huan;PAN Le;JIN Lu;ZHOU Rong(College of Chemistry and Chemical Engineering,Xinjiang Agricultural University,Ürümqi 830052,China;International Academy,Guizhou University of Finance and Economics,Guiyang 550000,China)

机构地区：[1]新疆农业大学化学化工学院,乌鲁木齐830052 [2]贵州财经大学国际学院,贵阳550000

出　　处：《农药》2023年第3期163-166,172,共5页Agrochemicals

基　　金：国家自然科学基金(21762042);新疆维吾尔自治区自然科学基金青年科学基金(2016D01B018)。

摘　　要：[目的]Ni催化偶联关环获得23个2-芳基苯(吡啶)并呋喃类化合物,考察其离体杀菌活性。[方法]通过1H NMR和13C NMR谱确认了目标化合物结构,采用菌丝生长速率法测定了其对茄交链孢、尖孢镰刀菌、灰葡萄孢、链格孢菌4种植物病原真菌抑制活性。[结果]化合物对供试真菌具有不同程度的抑制作用,5l和5s对链格孢的抑制作用显著,处理后96 h抑制率均在94%以上(50 mg/L)。[结论]化合物上取代基R1和R2对抑菌活性有较大影响,吡啶环的引入使得抑菌效果显著提高。[Aims]232-Aryl benzofuran or furopyridine derivatives were obtained via coupling-cyclization catalyzed with Ni.Their antifungal activities in vitro were investigated.[Methods]The structures of these derivatives were confirmed by~1H NMR and13C NMR.Additionally,their antifungal activities were evaluated by mycelial growth inhibition rate against 4 crop fungi(Alternaria solani,Fusarium oxysporum,Botrytis cinerea and A.alternata).[Results]Most of the compounds showed different degrees of inhibition against the tested fungi.5l and 5s had excellent antifungal activity against A.alternate,with inhibition rate(96 h)above 94%at 50 mg/L.[Conclusions]The activities of the compounds were significantly affected by the groups R1and R2,and greatly enhanced by the introduction of pyridine groups.

关 键 词：2-芳基苯并呋喃 抗真菌活性 植物病原真菌 

分 类 号：TQ460.3[化学工程—制药化工]