新型1,3,4-噁二唑类化合物的设计、合成及杀细菌活性  

Design,synthesis and bactericidal activity of novel 1,3,4-oxadiazole compounds

作　　者：杨佳欣 朱晨 柯岩 张静[1,2] 张立新 YANG Jia-xin;ZHU Chen;KE Yan;ZHANG Jing;ZHANG Li-xin(Institute of Functional Molecules,Shenyang University of Chemical Technology,Liaoning Key Laboratory of Green Functional Molecule Design and Development,Shenyang Key Laboratory of Targeted Pesticides,Shenyang 110142,China;Metisa Biotechnology Co.,Ltd.,Nanning 530000,China)

机构地区：[1]沈阳化工大学功能分子研究所,辽宁省绿色功能分子设计与开发重点实验室,沈阳市靶向农药重点实验室,沈阳110142 [2]广西思钺生物科技有限责任公司,南宁530000

出　　处：《农药》2023年第3期173-176,共4页Agrochemicals

基　　金：南宁市科学研究与技术开发计划项目立项资助,重大科技专项(20201043);南宁市创新创业领军人才“邕江计划”创业项目(2020002-1)。

摘　　要：[目的]发现结构新颖的高效杀细菌剂。[方法]以取代苯甲酸为起始原料,采用活性亚结构拼接策略。[结果]设计、合成了一系列1,3,4-噁二唑类化合物,其结构经1H NMR和ESI-MS确证。初步的温室生物活性测试结果表明,化合物7d具有优异的杀细菌活性,在测试质量浓度为400 mg/L时,化合物7d对甜瓜果斑病的防效高达91.71%,优于对照药剂硫酸链霉素。[结论]化合物7d可作为先导化合物进行进一步研究。[Aims]In order to discover novel bactericides with more effective activity.[Methods]A series of 1,3,4-oxadiazole compounds were designed and synthesized on the principle of biologically active factor splicing using substituted benzoic acid as the starting material.[Results]The structures were confirmed by~1H NMR and ESI-MS.The preliminary bioassay results in greenhouse showed that compound 7d had excellent bactericidal activity.At the test concentration of 400 mg/L,the control effect of compound 7d on bacterial fruit blotch was as high as 91.71%,which was better than that of the control agent streptomycin sulfate.[Conclusions]Compound 7d can be further studied as a lead compound.

关 键 词：1 3 4-噁二唑类 杀细菌剂 合成 甜瓜果斑病 

分 类 号：TQ460.3[化学工程—制药化工]