低温消毒剂防冻配方研究  

Study on anti-freezing formulas for low-temperature disinfectant

作　　者：梁辰[1] 张伟[1] 孙惠惠[1] 段弘扬 李陆瑶 沈瑾[1] 张流波[1] 王佳奇[1] LIANG Chen;ZHANG Wei;SUN Hui-hui;DUAN Hong-yang;LI Lu-yao;SHEN Jin;ZHANG Liu-bo;WANG Jia-qi(National Institute of Environmental Health,Chinese Center for Disease Control and Prevention,Beijing 100021 China)

机构地区：[1]中国疾病预防控制中心环境与健康相关产品安全所,北京100021

出　　处：《中国消毒学杂志》2023年第2期84-87,共4页Chinese Journal of Disinfection

基　　金：科技部重点研发计划(2021YFC0863000)。

摘　　要：目的研究氯化钠、氯化钙、氯化镁、乙醇和乙二醇等化学防冻成分用于低温消毒剂的防冻配方。方法分别观察不同浓度的单一成分和复合配方在实验室低温下(-18℃)存放不同时间(1、4、8和24 h)后的凝固情况,从而评价其防冻效果。结果在低温下(-18℃),单一成分的氯化钙(>26 g/100 mL)、氯化镁(>24 g/100 mL)、乙醇(>50%,v/v)、乙二醇(>39%,v/v)具有防冻效果;复合配方氯化钠(20 g/100 mL)+乙二醇(15%,v/v)、氯化钠(15 g/100 mL)+乙醇(15%,v/v)+乙二醇(10%,v/v),可以经济有效地实现-18℃下不凝固。结论本研究中的2种复合配方可以实现低温消毒剂的防冻目的,在低温消毒工作中可作为候选配方。Objective To study common chemical anti-freezing ingredients sodium chloride,calcium chloride,magnesium chloride,ethanol and ethylene glycol using as anti-freezing formulas for low-temperature disinfectant.Methods Different concentrations of single ingredient and compound ingredients stored at low temperature(-18°C)for 1,4,8 or 24 h to study the anti-freezing effects.Results Single anti-freezing ingredient such as calcium chloride(>26 g/100 mL),magnesium chloride(>24 g/100 mL),ethanol(>50%,v/v),ethylene glycol(>39%,v/v)had anti-freezing effect at-18°C.Two compound formulations could cost-effectively achieve anti-freezing effect at-18°C,they were sodium chloride(20 g/100 mL)+ethylene glycol(15%,v/v),sodium chloride(15 g/100 mL)+ethanol(15%,v/v)+ethylene glycol(10%,v/v).Conclusion The two compound formulations can achieve the purpose of anti-freezing effects,which can be used as candidate formulations in low-temperature disinfectant.

关 键 词：低温消毒剂 防冻剂 防冻效果 

分 类 号：R187[医药卫生—流行病学]