移植肾IgA肾病合并慢性钙调蛋白抑制剂肾毒性  

IgA nephropathy with chronic calcineurin inhibitor nephrotoxicity after kidney transplantation

作　　者：徐峰 曾彩虹 XU Feng;ZENG Caihong(National Clinical Research Center of Kidney Diseases,Jinling Hospital,Nanjing University School of Medicine,Nanjing 210016,China)

机构地区：[1]东部战区总医院、国家肾脏疾病临床医学研究中心、全军肾脏病研究所,南京210016

出　　处：《肾脏病与透析肾移植杂志》2023年第1期90-94,共5页Chinese Journal of Nephrology,Dialysis & Transplantation

基　　金：国家自然科学基金面上项目(82070793);江苏省卫计委“科教强卫”项目(ZDRCA2016098)。

摘　　要：青年男性患者,肾移植术后7年,应用吗替麦考酚酯、他克莫司、泼尼松等免疫抑制治疗,临床表现为大量蛋白尿伴少量镜下血尿,肾活检组织学为局灶节段性肾小球硬化,免疫荧光肾小球Ig A沉积,同时小动脉壁中膜和外膜见滴状透明变性。结合临床,考虑移植肾Ig A肾病合并钙调磷酸酶抑制剂肾毒性。A 34-year-old male presented with massive proteinuria and mild microscopic hematuria seven years after kidney transplantation,treated with immunosuppressive therapy of mycophenolate mofetil,tacrolimus and prednisone.Renal biopsy revealed focal segmental glomerulosclerosis with Ig A deposition,and nodular hyaline deposits in the media and adventitia of arterioles.The final diagnosis was allograft Ig A nephropathy with calcineurin inhibitor nephrotoxicity.

关 键 词：肾移植 IGA肾病 局灶节段性肾小球硬化 钙调磷酸酶抑制剂肾毒性 

分 类 号：R699.2[医药卫生—泌尿科学]