γ-聚谷氨酸的生物活性研究进展  

Research progress on biological activities of poly-γ-glutamic acid

作　　者：符恒 孙良 姜康 雷鹏[1,2] 王瑞 许宗奇 李莎[1] 徐虹 FU Heng;SUN Liang;JIANG Kang;LEI Peng;WANG Rui;XU Zongqi;LI Sha;XU Hong(College of Food Science and Light Industry,Nanjing Tech University,Nanjing 211816;Nanjing Shineking Biological Technology Company,Ltd.,Nanjing 210000)

机构地区：[1]南京工业大学食品与轻工学院,南京211816 [2]南京轩凯生物科技股份有限公司,南京210000

出　　处：《中国食品添加剂》2023年第3期333-341,共9页China Food Additives

基　　金：十三五国家重点研发计划课题“生物聚合物的构效关系研究及农业应用开发”(2021YFC2101703)。

摘　　要：聚谷氨酸(Poly-γ-glutamic acid,γ-PGA)是在一些特定的微生物中发现的天然聚氨基酸,是一种由L-谷氨酸或D-谷氨酸通过γ-酰胺键连接聚合而成的多功能肽,目前可以通过微生物发酵实现规模制备。γ-PGA具有促进矿物吸收、生物膜形成、植物促生、免疫调节、降血糖、抗氧化等一系列生物活性功能。为了更好地应用此种天然生物化学品,我们简单介绍了γ-PGA的结构,制备方法,从动物、植物、微生物三方面重点突出了其生物活性和应用前景,旨在探索其未来应用以及开发新型生物活性制品。As a natural poly-amino acid,poly-γ-glutamic acid(γ-PGA)is found in certain microorganisms.γ-PGA is a functional polypeptide where D-and L-glutamic acids are combined with γ-linkages. At present,it can be produced on a large scale through microbial fermentation. It has biological activities such as promoting mineral absorption,biofilm formation,plant growth,immune regulation,hypoglycemia and antioxidation. For better use of γ-PGA,this review introduced and summarized structure and source of γ-PGA as well as its preparation methods. Moreover,in order to explore its future application and develop new bioactive products,its bioactivity and application prospect in animal,plant and microorganism were highlighted.

关 键 词：Γ-PGA 生物活性 免疫功能 矿物质 动物 

分 类 号：R977.4[医药卫生—药品] R977.5[医药卫生—药学]