补肾生血方加减治疗老年股骨颈骨折半髋关节置换围手术期贫血的研究  

Efficacy of modified Bushen Shengxue decoction on perioperative anemia of half hip replacement for femoral neck fracture in the elderly

作　　者：范斌[1] 付永亮[2] FAN Bin;FU Yongliang(Mianyang Third People’s Hospital,Mianyang 621000,Sichuan,China;Mianyang Hospital of Traditional Chinese Medicine,Mianyang 621000,Sichuan,China)

机构地区：[1]绵阳市第三人民医院,四川绵阳621000 [2]绵阳市中医医院,四川绵阳621000

出　　处：《现代中西医结合杂志》2023年第1期50-54,共5页Modern Journal of Integrated Traditional Chinese and Western Medicine

基　　金：四川中医药文化传承与研究中心课题(2018Y003)。

摘　　要：目的观察补肾生血方加减治疗老年股骨颈骨折半髋关节置换围手术期贫血患者的疗效及对血红蛋白(Hb)、红细胞(RBC)、血细胞比容(HCT)的影响。方法将2018年3月—2020年3月在绵阳市中医医院骨伤科治疗的240例老年股骨颈骨折半髋关节置换围手术期贫血患者随机分为对照A组80例、对照B组80例、观察组80例。对照A组定期监测Hb,Hb低于70 g/L时给予输血治疗;对照B组给予多糖铁复合物胶囊治疗3周,观察组给予补肾生血方加减口服治疗3周。检测3组患者术前和术后1 d、1周、3周Hb、RBC、HCT水平,评价3组患者术后1 d和术后3周中医症状积分,比较3组患者临床治疗总有效率,记录3组患者不良反应发生率。结果术后1周、3周,3组患者Hb、RBC、HCT水平均明显高于术后1 d,术后3周均明显高于术后1周,且观察组上述指标均明显高于同期其他2组,对照B组均明显高于同期对照A组,差异均有统计学意义(P均<0.05)。3组患者术后3周的中医症状积分均明显低于术后1 d,且观察组均明显低于同期其他2组,对照B组明显低于对照A组,差异均有统计学意义(P均<0.05)。对照A组、对照B组、观察组总有效率分别为75.00%(60/80)、87.50%(70/80)、96.25%(77/80),观察组明显高于其他2组(P均<0.05),对照B组明显高于对照A组(P<0.05)。对照A组、对照B组、观察组不良反应发生率分别为15.00%(12/80)、7.50%(6/80)、1.25%(1/80),观察组明显低于其他2组(P均<0.05),对照B组明显低于对照A组(P<0.05)。结论补肾生血方加减治疗老年股骨颈骨折半髋关节置换围手术期贫血疗效显著,可有效缓解贫血症状,且安全性高。Objective It is to observe the curative effect of modified Bushen Shengxue decoction on perioperative anemia of half hip replacement for femoral neck fracture in the elderly and its influence on hemoglobin(Hb),red blood cell(RBC)and hematocrit(HCT).Methods Two hundreds and forty elderly patients with anemia during the perioperative period of hemi-hip replacement for femoral neck fracture treated in the Department of Orthopedics and Traumatology of Mianyang Hospital of Traditional Chinese Medicine from March 2018 to March 2020 were randomly divided into control group A(80 cases),control group B(80 cases)and observation group(80 cases).In control group A,Hb was monitored regularly,and blood transfusion was given when Hb was lower than 70 g/L;The control group B was treated with polysaccharide-iron complex capsule for 3 weeks,and the observation group was treated with modified Bushen Shengxue decoction by oral administration for 3 weeks.The levels of Hb,RBC and HCT of the patients in the three groups were measured before treatment and 1 day,1 week and 3 weeks after operation,and the TCM symptom scores of the patients in the three groups were evaluated 1 day and 3 weeks after operation,the total effective rates of clinical treatment of the three groups were compared,and the incidences of adverse reactions in the three groups were recorded.Results The levels of Hb,RBC and HCT 1 week and 3 weeks after operation were significantly higher than those 1 day after the operation in the three groups,and the above indexes 3 weeks after surgery were significantly higher than those1 week after surgery,the indexes in the observation group were significantly higher than those in the other 2 groups during the same period,and those in the control B group were significantly higher than those in the control A group during the same period,and the differences were statistically significant(all P<0.05).The TCM symptom scores of the patients in the three groups 3 weeks after surgery were significantly lower than that 1 day after operation

关 键 词：补肾生血方 老年股骨颈骨折 半髋关节置换 围手术期 贫血 

分 类 号：R683.42[医药卫生—骨科学]