尿碘水平对Graves甲亢患者^(131)I治疗效果的影响观察  

Effect of urinary iodine level on ^(131)I treatment in Graves hyperthyroidism patients

作　　者：胡睿婷 李斌[2] HU Ruiting;LI Bin(Department of Endocrinology,Linyi Traditional Chinese Medicine Hospital,Linyi,Shandong 276002,China;Radionuclide Treatment Ward,Linyi People’s Hospital,Linyi,Shandong 276003,,China)

机构地区：[1]临沂市中医医院内分泌一科,山东临沂276002 [2]临沂市人民医院核素治疗病房,山东临沂276003

出　　处：《医药前沿》2022年第36期45-47,共3页Journal of Frontiers of Medicine

摘　　要：目的:观察尿碘水平对Graves甲亢患者^(131)I治疗效果的影响。方法:分析2020年9月—2021年6月在临沂市人民医院首次接受^(131)I治疗的Graves甲亢患者242例。测定所有患者的尿碘浓度,按《中国居民补碘指南》的标准,根据尿碘水平将患者分为碘缺乏组(<100μg/L)(n=155)、碘足量组(100~199μg/L)(n=57)、碘超足量组(200~299μg/L)(n=18)和碘过量组(≥300μg/L)(n=12)。所有患者均采用计算剂量法给予一次性^(131)I治疗,并在治疗后门诊规律随访6个月,以确定患者的治疗效果。结果:治疗前,除碘超足量组的性别外,其他各组患者的性别、年龄、服碘剂量、游离三碘甲状腺原氨酸(FT3)、游离四碘甲状腺原氨酸(FT4)、促甲状腺激素(TSH)、甲状腺过氧化物酶抗体(TPOAb)、抗甲状腺激素受体抗体(TRAb)等比较,差异均无统计学意义(P>0.05)。治疗后随访6个月,不同尿碘水平状态的各组患者的治疗效果比较,差异均无统计学意义(P>0.05)。Logistic回归分析也显示,除病程外,其余各指标均与^(131)I的治疗效果无关。结论:尿碘水平对Graves甲亢患者^(131)I治疗效果无明显影响。Objective To investigate the effect of urinary iodine level on ^(131)I in Graves hyperthyroidism patients.Methods A total of 242 Graves’hyperthyroidism patients,48 males and 194 females,aged 44(33,54),who received ^(131)I treatment for the first time in Linyi People’s Hospital from September 2020 to June 2021,were analyzed.Urine iodine concentration of all patients was determined,and patients were divided into iodine deficiency group(<100μg/L)(n=155),sufficient iodine group(100~199μg/L)(n=57),over-sufficient iodine group(200~299μg/L)(n=18)and over-iodine group(≥300μg/L)(n=12)according to the level of urinary iodine.All patients were treated with ^(131)I at one time using the computed dose method and followed up regularly for 6 months in the outpatient department to determine the outcome of treatment.Results Before treatment,there were no statistically significant differences in gender,age,iodine dose,FT3,FT4,TSH,TPOAb and TRAb of patients in other groups except the gender of over-sufficient iodine group.There was no statistical difference in the therapeutic effect of patients with different iodine nutritional status in the 6 months follow-up after treatment.Logistic regression analysis also showed that,except the course of disease,the other indicators were not related to the therapeutic effect of ^(131)I.Conclusion Urinary iodine level has no significant effect on ^(131)I treatment in Graves hyperthyroidism patients.

关 键 词：尿碘 GRAVES甲亢 ^(131)I 治疗效果 

分 类 号：R335[医药卫生—人体生理学]