新活素注射液联合速尿治疗难治性心力衰竭疗效及对心功能血气指标和血清NT-pro BNP PCT水平的影响  

Curative Effect of Recombinant Human Brain Natriuretic Peptide for Injection Combined with Furosemide in the Treatment of Refractory Heart Failure and the Influence on Cardiac Function,Blood Gas Indexes Serum NT-pro BNP and PCT Levels

作　　者：姜卓 周洁 杨爱祥[1] 陶唯益 王耀东 JIANG Zhuo;ZHOU Jie;YANG Aixiang(Suzhou Hospital Affiliated to Nanjing Medical University,Jiangsu Suzhou 215000,China)

机构地区：[1]南京医科大学附属苏州医院重症医学科,江苏苏州215000

出　　处：《河北医学》2023年第3期402-406,共5页Hebei Medicine

基　　金：2021年度南京医科大学姑苏学院科研项目,(编号:GSKY20210201)。

摘　　要：目的:探讨难治性心力衰竭采用新活素注射液联合速尿治疗效果及对心功能、血气指标和血清N末端脑钠肽前体(NT-pro BNP)、降钙素原(PCT)水平的影响。方法:回顾性收集2018年1月至2021年12月于本院就诊的108例难治性心力衰竭患者的临床资料,根据不同用药方法将患者分入对照组(n=54,速尿治疗)和观察组(n=54,速尿联合新活素注射液治疗),比较两组临床疗效、心功能、血气指标、血清NT-pro BNP、PCT水平。结果:观察组治疗有效率94.44%高于对照组的81.48%(P<0.05);观察组心搏量、左室射血分数、左室收缩及舒张末期内径治疗前后差值均高于对照组(P<0.05);观察组动脉血氧分压(PaO 2)、动脉血二氧化碳分压(PaCO 2)、pH值治疗前后差值均高于对照组(P<0.05);观察组血清NT-pro BNP、PCT治疗前后差值均高于对照组(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:新活素注射液联合速尿治疗难治性心力衰竭效果显著,可有效改善患者心功能及血气指标,调节血清NT-pro BNP、PCT水平,临床可借鉴。Objective:To investigate the effect of recombinant human brain natriuretic peptide for injection combined with furosemide in the treatment of refractory heart failure,and the influence on cardiac function,blood gas indexes,serum N-terminal pro-brain natriuretic peptide(NT-pro BNP)and procalcitonin(PCT)levels.Methods:The clinical data of 108 cases of refractory heart failure treated in our hospital from January 2018 to December 2021 were retrospectively collected.They were divided into a control group(n=54,furosemide)and an observation group(n=54,furosemide combined with Recombinant Human Brain Natriuretic Peptide for Injection)by different medication methods.Clinical effects,cardiac function,blood gas indexes,serum NT-pro BNP and PCT levels were compared between the two groups.Results:The treatment response rate in the observation group(94.44%)was higher than that in the control group(81.48%)(P<0.05).The values of stroke volume left ventricular ejection fraction,left ventricular end-systolic diameter,and left ventricular end-diastolic diameter in the observation group before and after treatment were higher than those in the control group(P<0.05).The differences in arterial partial pressure of oxygen(PaO 2),arterial partial pressure of carbon dioxide(PaCO 2),and pH values in the observation group before and after treatment were higher than those in the control group(P<0.05).The differences in serum NT-pro BNP and PCT levels in the observation group before and after treatment were higher than those in the control group(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Recombinant human brain natriuretic peptide for injection combined with furosemide is effective in the treatment of refractory heart failure,which can effectively improve the patient's cardiac function and blood gas indexes,and regulate serum NT-pro BNP and PCT levels.

关 键 词：心力衰竭 新活素注射液 速尿 心功能 血清N末端脑钠肽前体 降钙素原 

分 类 号：R541.6[医药卫生—心血管疾病]