过敏性鼻炎不同证型治疗方的药味配伍共性特点研究  

Study on the Common Characteristics of the Compatibility of Medicinal Tastes in Allergic Rhinitis of Different Syndromes

作　　者：王彬 金锐 刘静[2] 韩江云 刘蕊 WANG Bin;JIN Rui;LIU Jing;HAN Jiangyun;LIU Rui(Department of Pharmacy,School of Medicine Shanghai Sixth People's Hospital Affiliated to School of Medicine,Shanghai Jiao Tong University,Shanghai 200233,China;Department of Pharmacy,Xiyuan Hospital,China Academy of Chinese Medical Sciences,Beijing 100091,China;Department of Pharmacy,the Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University,Luzhou 646000,China;Department of Pharmacy,Beijing Fengtai District Mental Health Center,Beijing 100076,China)

机构地区：[1]上海交通大学医学院附属第六人民医院药剂科,上海200233 [2]中国中医科学院西苑医院药学部,北京100091 [3]西南医科大学附属中医医院药剂科,泸州646000 [4]北京市丰台区心理卫生中心药剂科,北京100076

出　　处：《医药导报》2023年第4期488-495,共8页Herald of Medicine

基　　金：中国中医科学院科技创新工程重大攻关项目(CI2021A03805);上海市卫生和计划生育委员会科研基金资助项目(20164Y0072)。

摘　　要：目的在“汤液经法图”理论体系下,探索过敏性鼻炎不同证型治疗方在药味配伍方面的共性特点。方法收集过敏性鼻炎中医诊疗指南、临床路径以及系统综述涵盖的中药治疗方和治疗过敏性鼻炎的中成药,明确其配伍结构和功效特点,统计其药味分布情况。与“汤液经法图”中肺系疾病治疗的补味(酸味)、泻味(咸味)和化味(辛味)做比对,计算药味占比,并分析母子同治的组方特点。结果统计得到过敏性鼻炎不同证型的治疗方33首,包括小青龙汤、补中益气汤加减方、辛夷清肺饮加减方、辛夷鼻炎丸、通窍鼻炎颗粒等。其中,组方中“辛酸咸”占比>80%24首,占比60%~80%6首,占比40%~60%3首。方中的苦、甘味用药则主要集中在肺脾同治或肺肾同治的方剂中。结论从“汤液经法图”角度看,单纯的过敏性鼻炎治疗以治肺为主,药味以“辛酸咸”为主。苦甘药味的中药往往用于肺脾同治或肺肾同治的复杂情形。Objective Based on the theoretical system of the“Tangye Jingfa map”,the study aims to explore the common characteristics of allergic rhinitis of different syndromes in the compatibility of medicine and taste in this paper.Methods The traditional Chinese medicines diagnosis and treatment guidelines for allergic rhinitis,clinical pathways,and the traditional Chinese medicine treatment prescriptions covered by the systematic review and the proprietary traditional Chinese medicines for the treatment of allergic rhinitis were collected.The prescription compatibility structure and efficacy characteristics were clarified,and the distribution of herbal tastes was statistically analyzed.Compared with the tonification flavor(sour),purgation flavor(salty),and harmonization flavor(pungent)in the treatment of lung diseases in the“Tangye Jingfa map”,the proportion of medicinal taste was calculated,and the characteristics of the combination was analyzed.Results A total of 33 prescriptions were collected for different syndrome types of allergic rhinitis,including Xiaoqinglong decoction,Buzhong Yiqi decoction,Xinyiqingfei decoction,Magnolia Biyan Pills,and Tongqiao Biyan granules.Among them,"sour and salty"herbs account for a proportion above 80%in 24 prescriptions,six prescriptions account for a proportion between 60%and 80%,and three prescriptions account for a proportion between 40%and 60%,and 0 prescription accounts for a proportion below 40%.Among them,bitter and sweet herbs are mainly concentrated in the lung and spleen or lung and kidney prescriptions.Conclusion From the“Tangye Jingfa map”perspective,the treatment of simple allergic rhinitis is mainly to treat the lungs,and the medicinal taste is mainly"bitter and salty".Traditional Chinese medicine with bitter-sweet flavor is often used in complex situations where the lungs and spleen are treated together,or the lungs and kidneys are treated together.

关 键 词：汤液经法图 辅行诀 过敏性鼻炎 辨证论治 鼻鼽 中药 

分 类 号：R944[医药卫生—药剂学] R765[医药卫生—药学]