布地奈德、猪肺磷脂注射液联合高频振荡叠加常频通气治疗重度早产儿呼吸窘迫综合征的临床效果  

Clinical effect of budesonide and poractant alfa injection combined with high-frequency oscillatory ventilation and conventional mechanical ventilation in the treatment of premature infants with severe respiratory distress syndrome

作　　者：田玉凤 郭丽丽 TIAN Yufeng;GUO Lili(Pediatrics Department,the First Hospital of Yulin,Yulin 719000,China)

机构地区：[1]陕西省榆林市第一医院儿内科,陕西榆林719000

出　　处：《临床医学研究与实践》2023年第9期58-60,共3页Clinical Research and Practice

摘　　要：目的探讨布地奈德、猪肺磷脂注射液联合高频振荡叠加常频通气治疗重度早产儿呼吸窘迫综合征的临床效果。方法选取2018年3月至2021年3月于本院接受治疗的60例重度早产儿呼吸窘迫综合征患儿为研究对象,按治疗方法不同将其分为对照组、观察组,各30例。对照组采用高频振荡叠加常频通气治疗,观察组在对照组基础上给予布地奈德、猪肺磷脂注射液治疗。比较两组患儿的临床疗效。结果观察组的治疗总有效率高于对照组(P<0.05)。治疗后,观察组的血氧分压(PO_(2))、氧合指数(OI)高于对照组,二氧化碳分压(PCO_(2))低于对照组(P<0.05)。治疗后,观察组的转化生长因子-β1(TGF-β1)、基质金属蛋白酶-16(MMP-16)、核因子-κB(NF-κB)水平均低于对照组(P<0.05)。结论布地奈德、猪肺磷脂注射液联合高频振荡叠加常频通气治疗重度早产儿呼吸窘迫综合征的效果显著,可改善患儿的血气指标,降低TGF-β1、MMP-16、NF-κB水平。Objective To study the clinical effect of budesonide and poractant alfa injection combined with high-frequency oscillatory ventilation and conventional mechanical ventilation in the treatment of premature infants with severe respiratory distress syndrome.Methods Sixty premature infants with severe respiratory distress syndrome who received treatment in our hospital from March 2018 to March 2021 were selected as the research objects and divided into control group and observation group according to different treatment methods,with 30 cases in each group.The control group was treated with high-frequency oscillatory ventilation and conventional mechanical ventilation,and the observation group was treated with budesonide and poractant alfa injection on the basis of the control group.The clinical effects of the two groups were compared.Results The total effective rate of treatment in the observation group was higher than that in the control group(P<0.05).After treatment,the partial pressure of oxygen(PO_(2)),oxygenation index(OI)in the observation group were higher than those in the control group,and the partial pressure of carbon dioxide(PCO_(2))was lower than that in the control group(P<0.05).After treatment,the levels of transforming growth factor-β1(TGF-β1),matrix metalloproteinase-16(MMP-16)and nuclear factor-κB(NF-κB)in the observation group were lower than those in the control group(P<0.05).Conclusion Budesonide and poractant alfa injection combined with high-frequency oscillatory ventilation and conventional mechanical ventilation have significant effects in the treatment of premature infants with severe respiratory distress syndrome,it can improve blood gas indexes and reduce the levels of TGF-β1,MMP-16 and NF-κB.

关 键 词：早产儿 呼吸窘迫综合征 布地奈德 猪肺磷脂注射液 

分 类 号：R72[医药卫生—儿科]