马来酸麦角新碱联合缩宫素治疗和预防剖宫产术后出血的临床价值  

Clinical value of ergometrine maleate combined with oxytocin in the treatment and prevention of hemorrhage after cesarean section

作　　者：冯娟宁 杨莎 蒋晓颖 FENG Juanning;YANG Sha;JIANG Xiaoying(Qishan County Hospital,Baoji 722400;Baoji Maternal and Child Health Hospital,Baoji 721000,China)

机构地区：[1]岐山县医院,陕西宝鸡722400 [2]宝鸡市妇幼保健院,陕西宝鸡721000

出　　处：《临床医学研究与实践》2023年第9期115-118,共4页Clinical Research and Practice

摘　　要：目的探讨马来酸麦角新碱联合缩宫素治疗和预防剖宫产术后出血的临床价值。方法选取2017年1月至2020年12月我院收诊的74例剖宫产产妇为研究对象,遵循随机原则将其分为对照组和观察组,每组37例。对照组接受缩宫素治疗,观察组接受马来酸麦角新碱联合缩宫素治疗。比较两组产后2、4、24 h的总出血量;比较两组治疗前、治疗2 h后的收缩压(SBP)、舒张压(DBP)及治疗3 d后的治疗副反应量表(TESS)评分;比较两组治疗24 h后的产后出血、产后贫血发生率;比较两组治疗前、治疗2 h后的凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、纤维蛋白原(Fbg)水平。结果观察组产后2、4、24 h的总出血量均少于对照组,差异具有统计学意义(P<0.05)。治疗前,两组的SBP、DBP比较,差异无统计学意义(P>0.05);治疗2 h后,观察组的SBP、DBP均高于对照组,差异具有统计学意义(P<0.05);治疗3 d后,观察组的TESS评分低于对照组,差异具有统计学意义(P<0.05)。观察组治疗24 h后的产后出血、产后贫血发生率均低于对照组,差异具有统计学意义(P<0.05)。治疗前,两组的PT、APTT、Fbg水平比较,差异无统计学意义(P>0.05);治疗2 h后,观察组的PT、APTT短于对照组,Fbg水平高于对照组,差异具有统计学意义(P<0.05)。结论马来酸麦角新碱联合缩宫素治疗和预防剖宫产术后出血的效果显著,能够改善血压水平,降低产后出血、贫血发生率,且用药安全性高,对患者预后改善有积极作用,值得临床推广。Objective To explore the clinical value of ergometrine maleate combined with oxytocin in the treatment and prevention of hemorrhage after cesarean section.Methods A total of 74 cesarean section women admitted in our hospital from January 2017 to December 2020 were selected as the research objects and randomly divided into control group and observation group,with 37 cases in each group.The control group received oxytocin treatment,and the observation group received ergometrine maleate combined with oxytocin treatment.The total blood loss at 2,4 and 24 h postpartum in the two groups was compared;the systolic blood pressure(SBP)and diastolic blood pressure(DBP)before treatment and after 2 h of treatment and Treatment Emergent Symptom Scale(TESS)score after 3 d of treatment of the two groups were compared;the incidences of postpartum hemorrhage and postpartum anemia after 24 h of treatment in the two groups were compared;the prothrombin time(PT),activated partial thromboplastin time(APTT)and fibrinogen(Fbg)level were compared between the two groups before treatment and after 2 h of treatment.Results The total blood loss at 2,4 and 24 h postpartum in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).Before treatment,there were no significant differences in SBP and DBP between the two groups(P>0.05);after 2 h of treatment,the SBP and DBP in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05);after 3 d of treatment,the score of TESS in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).The incidences of postpartum hemorrhage and postpartum anemia after 24 h of treatment in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).Before treatment,there were no significant differences in PT,APTT and Fbg level between the two groups(P>0.05);afte

关 键 词：马来酸麦角新碱 缩宫素 剖宫产 产后出血 产后贫血 

分 类 号：R714.7[医药卫生—妇产科学]