妊娠期合并症对胎盘屏障功能的影响  

Effects of pregnancy complications on placental barrier function

作　　者：李飞 丁爱玲 万慧敏 刘玲艳 董旭东[2] LI Fei;DING Ailing;WAN Huimin;LIU Lingyan;DONG Xudong(School of Medicine,Kunming University of Science and Technology,Kunming,Yunnan 650500,China;Department of Obstetrics,the First People’s Hospital of Yunnan Province/The Affiliated Hospital of Kunming University of Science and Technology,Kunming,Yunnan 650500,China)

机构地区：[1]昆明理工大学医学院,昆明650500 [2]云南省第一人民医院/昆明理工大学附属医院产科,昆明650500

出　　处：《重庆医学》2023年第6期820-823,共4页Chongqing medicine

基　　金：国家自然科学基金项目(42167060);云南省高层次卫生健康技术人才培养专项(L-2018006);云南省妇产疾病临床医学研究中心项目(2022YJZX-FC18)。

摘　　要：目的研究不同妊娠期合并症对胎盘屏障功能的影响。方法选取2021年5月至2022年5月云南省第一人民医院产科住院分娩的62例孕妇为研究对象,根据孕妇健康状况分为妊娠期糖尿病组(n=16),妊娠期高血压疾病组(n=16)和正常孕产妇组(n=30),采用电感耦合等离子质谱法(ICP-MS)测定并比较各组母血、脐血和胎盘中铅水平。结果正常孕产妇组和妊娠期糖尿病组铅的分布为胎盘最高、母血次之、脐血最低,妊娠期高血压疾病组铅分布为胎盘最高、脐血次之、母血最低。与正常孕产妇组比较,妊娠期糖尿病组母血、胎盘及脐血铅水平更高,妊娠期高血压疾病组母血、脐血铅水平更高,差异有统计学意义(P<0.05)。妊娠期糖尿病组(75.0%)和妊娠期高血压疾病组(62.5%)铅胎盘屏障率低于正常孕产妇组(76.6%)。结论妊娠期合并症可使胎盘屏障功能降低。Objective To study the effects of different pregnancy complications on placental barrier function.Methods A total of 62 pregnant women who gave birth in the Department of Obstetrics,the First People’s Hospital of Yunnan Province from May 2021 to May 2022 were selected as the research objects.According to the health status of pregnant women,they were divided into gestational diabetes group(n=16),gestational hypertension group(n=16)and normal pregnant women group(n=30).The lead levels in maternal blood,umbilical blood and placenta were determined and compared by inductively coupled plasma mass spectrometry(ICP-MS).Results The distribution of lead in normal pregnant women and gestational diabetes group was the highest in placenta,followed by maternal blood and the lowest in umbilical blood.The distribution of lead in gestational hypertension group was the highest in placenta,followed by umbilical blood and the lowest in maternal blood.Compared with normal pregnant women group,lead levels in maternal blood,placenta,and umbilical blood were higher in gestational diabetes group,lead levels in maternal blood and umbilical blood were higher in the gestational hypertension group,the difference was statistically significant(P<0.05).The lead placental barrier rate in gestational diabetes(75.0%)and gestational hypertension(62.5%)was lower than that in normal pregnant women group(76.6%).Conclusion Pregnancy complication can reduce the barrier function of the placenta.

关 键 词：铅 妊娠期糖尿病 妊娠期高血压疾病 胎盘屏障 母胎健康 

分 类 号：R714.25[医药卫生—妇产科学]