穿心莲内酯促进骨折骨愈合作用机制的研究进展  

Research progress on mechanism of andrographolide in promoting bone healing of fracture

作　　者：谢加舒 刘卫峰 朱桃燕 XIE Jia-shu;LIU Wei-feng;ZHU Tao-yan(Department of Anesthesiology,The 904th Hospital of the Joint Service Support Force of the Chinese People's Liberation Army(Wuxi Taihu Hospital),Wuxi 214000,China;Department of Orthopedics,The 904th Hospital of the Joint Service Support Force of the Chinese People's Liberation Army(Wuxi Taihu Hospital),Wuxi 214000,China;Operation Room,The 904th Hospital of the Joint Service Support Force of the Chinese People's Liberation Army(Wuxi Taihu Hospital),Wuxi 214000,China)

机构地区：[1]中国人民解放军联勤保障部队第九〇四医院(无锡市太湖医院)麻醉科,江苏无锡214000 [2]中国人民解放军联勤保障部队第九〇四医院(无锡市太湖医院)骨科,江苏无锡214000 [3]中国人民解放军联勤保障部队第九〇四医院(无锡市太湖医院)手术室,江苏无锡214000

出　　处：《现代药物与临床》2023年第2期488-492,共5页Drugs & Clinic

摘　　要：骨折后的愈合状态直接影响患者的生活质量,如何提高骨折患者骨愈合效果是亟待解决的问题。穿心莲内酯是穿心莲中主要活性成分,可能通过促进成骨细胞增殖,抑制核因子κB(NF-κB)信号通路激活,激活Wnt/β-连环蛋白(Wnt/βcatenin)信号通路,调节护骨素/细胞核因子κB受体活化因子配基(OPG/RANKL)信号通路,调节成骨基因表达产物,改善软骨细胞功能,抑制雌激素相关受体α(ERRα)信号通路等多途径促使骨愈合。总结了穿心莲内酯促进骨折骨愈合作用及其作用机制,希望为穿心莲内酯的临床使用提供依据。Healing state after fracture directly affects the quality of life of patients,and how to improve the bone healing effect of fracture patients is an urgent problem to be solved.Andrographolide is the main active component in Andrographis Herba,which may promote osteoblast proliferation,inhibit the activation of NF-κB signaling pathway,activate Wnt/β-catenin signaling pathway,regulate OPG/RANKL signaling pathway,regulate the expression product of osteoblast gene,improves the function of chondrocytes,inhibit estrogen related receptorsαsignal path,and other multiple ways to promote bone healing.This article summarized the effect and its mechanism of andrographolide in promoting bone healing of fracture,hoping to provide evidence based support for the clinical use of andrographolide.

关 键 词：穿心莲内酯 骨愈合 成骨细胞增殖 核因子ΚB信号通路 Wnt/β-连环蛋白信号通路 护骨素/细胞核因子κB受体活化因子配基信号通路 软骨细胞功能 

分 类 号：R977[医药卫生—药品]